Fonsecaea nubica
| Fonsecaea nubica | |
|---|---|
Scientific classification  | |
| Kingdom: | Fungi |
| Division: | Ascomycota |
| Class: | Eurotiomycetes |
| Order: | Chaetothyriales |
| Family: | Herpotrichiellaceae |
| Genus: | Fonsecaea |
| Species: | F. nubica |
| Binomial name | |
| Fonsecaea nubica Najafzadeh et al., 2010 | |
Fonsecaea nubica is a species of fungi from the family Herpotrichiellaceae. F. nubica is known to cause a serious subcutaneous infection known as chromoblastomycosis. F. nubica was identified as a distinct species in 2010 using multilocus molecular data.[1]
Characteristics
Fonsecaea nubica produces dark, velvety colonies with Cladiosporium-type conidia.[2] F. nubica possesses dark brown septate hyphae with conidiophores that are highly branched at the tips.[3]
Fonsecaea nubica is classified as a dematiaceous mold, a group of fungi that possess melanin in their cell walls.[4] The presence of melanin in this fungi's cell wall causes their hyphal structures to appear brown under microscopy.
Human disease
Fonsecaea nubica is an prominent causative agent of chromoblastomycosis, a chronic fungal infection of the skin and subcutaneous tissue.[5] Infection typically occurs following traumatic inoculation of the pathogen into the wound.[6] This species is more predominantly encountered in tropical regions.[7] Symptoms of chromoblastomycosis include cauliflower-like lesions.[8]
Treatment
Chromoblastomycosis is difficult to treat. Itraconazole is usually the first-line therapy for chromoblastomycosis, with cure rates ranging from 15-80%.[9]
References
- ↑ Najafzadeh, M. J.; Sun, J.; Vicente, V.; Xi, L.; van den Ende, A. H. G. Gerrits; de Hoog, G. S. (2010). "Fonsecaea nubica sp. nov, a new agent of human chromoblastomycosis revealed using molecular data". Medical Mycology. 48 (6): 800–806. doi:10.3109/13693780903503081. ISSN 1369-3786. PMID 20302550.
- ↑ "Journal of mycology and infection". e-jmi.org (in Korean). doi:10.17966/JMI.2021.26.2.45. Retrieved 2026-05-17.
- ↑ Cateau, Estelle; Cante, Vincent; Garcia Hermoso, Dea; Rodier, Marie-Helene (2014). "Case of Fonsecaea nubica chromoblastomycosis from the French territory of Mayotte". JMM Case Reports. 1 (4) e004218. doi:10.1099/jmmcr.0.004218. ISSN 2053-3721. PMC 5415939. PMID 28663818.
- ↑ Wong, Eunice H.; Revankar, Sanjay G. (2016). "Dematiaceous Molds". Infectious Disease Clinics of North America. 30 (1): 165–178. doi:10.1016/j.idc.2015.10.007. ISSN 1557-9824. PMID 26897066.
- ↑ CDC (2026-01-30). "Clinical Overview of Chromoblastomycosis". Chromoblastomycosis. Retrieved 2026-05-17.
- ↑ Kurien, George; Sugumar, Kavin; Sathe, Nishad C.; Chandran, Veena (2026), "Chromoblastomycosis", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 29261968, retrieved 2026-05-17
- ↑ CDC (2026-01-30). "Clinical Overview of Chromoblastomycosis". Chromoblastomycosis. Retrieved 2026-05-17.
- ↑ Cateau, Estelle; Cante, Vincent; Garcia Hermoso, Dea; Rodier, Marie-Helene (2014). "Case of Fonsecaea nubica chromoblastomycosis from the French territory of Mayotte". JMM Case Reports. 1 (4) e004218. doi:10.1099/jmmcr.0.004218. ISSN 2053-3721. PMC 5415939. PMID 28663818.
- ↑ CDC (2026-01-30). "Clinical Overview of Chromoblastomycosis". Chromoblastomycosis. Retrieved 2026-05-17.