FSAF1

FSAF1
Identifiers
Aliases	FSAF1, chromosome 1 open reading frame 131, C1orf131, 40S Small Subunit Processome Assembly Factor 1, CPERP-A
External IDs	MGI: 1913773; GeneCards: FSAF1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	231,241,187 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	125,589,859 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; secondary oocyte; ; tibia; ; duodenum; ; mucosa of transverse colon; ; pancreatic epithelial cell; ; jejunal mucosa; ; rectum; ; parietal pleura; ; endothelial cell;
	Top expressed in
	otic vesicle; ; interventricular septum; ; otic placode; ; cumulus cell; ; primitive streak; ; saccule; ; epiblast; ; somite; ; abdominal wall; ; embryo;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	128061
	66523
	ENSG00000143633
	ENSMUSG00000031984
	Q8NDD1
	Q8CIL4
	NM_152379; NM_001300830
	NM_025615
	NP_001287759; NP_689592
	NP_079891
	Wikidata
View/Edit Human	View/Edit Mouse

40S small subunit processome assembly factor 1 is a protein that in humans is encoded by the gene FSAF1.^[5] The FSAF1 protein participates in assembling ribosomes (ribosome biogenesis) in the nucleolus.^[5] In particular, it is part of the ribosome small subunit (SSU) processome, which is the earliest precursor to the SSU.^[5]

Gene

In humans FSAF1 is located on the minus strand of chromosome 1 and on the cytogenetic band 1q42.2 along with 193 other genes.^[6] Notably, the gene upstream of FSAF1 is GNPAT, and the gene downstream of FSAF1 is TRIM67. When this gene is transcribed in humans, FSAF1 most often forms an mRNA of 1458 base pairs long which is composed of seven exons. There are at least nine others alternative splice forms in humans that produce proteins. They range in size from 129 base pairs (2 exons) to 1458 base pairs (7 exons).^[7]

Protein

The human protein has been shown to be both phosphorylated and acetylated.^[8]^[9]^[10]^[11]^[12]^[13]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143633 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031984 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "Q8NDD1 · FSAF1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-07-31.
↑ "Browse Homo sapiens ORF cDNA clones by chromosome 1, map 1q42, page 1". Archived from the original on 2015-05-18. Retrieved 2015-04-27.
↑ "AceView: Gene:C1orf131, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView".
↑ Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M (January 2010). "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis". Science Signaling. 3 (104): ra3. doi:10.1126/scisignal.2000475. PMID 20068231. S2CID 24775963.
↑ Wang B, Malik R, Nigg EA, Körner R (December 2008). "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis". Analytical Chemistry. 80 (24): 9526–9533. doi:10.1126/scisignal.2000475. PMID 20068231. S2CID 24775963. Retrieved April 26, 2015.
↑ Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–1166. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.
↑ Kim D, Hahn Y (July 9, 2011). "Identification of novel phosphorylation modification sites in human proteins that originated after the human–chimpanzee divergence". Bioinformatics. 27 (18): 2494–501. doi:10.1093/bioinformatics/btr426. PMID 21775310.
↑ Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP (August 2008). "A quantitative atlas of mitotic phosphorylation". Proceedings of the National Academy of Sciences of the United States of America. 105 (31): 10762–10767. Bibcode:2008PNAS..10510762D. doi:10.1073/pnas.0805139105. PMC 2504835. PMID 18669648.
↑ Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M (August 2010). "Lysine acetylation targets protein complexes and co-regulates major cellular functions". Science. 325 (5942): 834–40. Bibcode:2009Sci...325..834C. doi:10.1126/science.1175371. hdl:11858/00-001M-0000-0010-58F4-F. PMID 19608861. S2CID 206520776.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143633 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031984 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 3 "Q8NDD1 · FSAF1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-07-31.

[6] "Browse Homo sapiens ORF cDNA clones by chromosome 1, map 1q42, page 1". Archived from the original on 2015-05-18. Retrieved 2015-04-27.

[7] "AceView: Gene:C1orf131, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView".

[Olsen-8] Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M (January 2010). "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis". Science Signaling. 3 (104): ra3. doi:10.1126/scisignal.2000475. PMID 20068231. S2CID 24775963.

[Wang-9] Wang B, Malik R, Nigg EA, Körner R (December 2008). "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis". Analytical Chemistry. 80 (24): 9526–9533. doi:10.1126/scisignal.2000475. PMID 20068231. S2CID 24775963. Retrieved April 26, 2015.

[10] Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–1166. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.

[11] Kim D, Hahn Y (July 9, 2011). "Identification of novel phosphorylation modification sites in human proteins that originated after the human–chimpanzee divergence". Bioinformatics. 27 (18): 2494–501. doi:10.1093/bioinformatics/btr426. PMID 21775310.

[12] Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP (August 2008). "A quantitative atlas of mitotic phosphorylation". Proceedings of the National Academy of Sciences of the United States of America. 105 (31): 10762–10767. Bibcode:2008PNAS..10510762D. doi:10.1073/pnas.0805139105. PMC 2504835. PMID 18669648.

[13] Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M (August 2010). "Lysine acetylation targets protein complexes and co-regulates major cellular functions". Science. 325 (5942): 834–40. Bibcode:2009Sci...325..834C. doi:10.1126/science.1175371. hdl:11858/00-001M-0000-0010-58F4-F. PMID 19608861. S2CID 206520776.

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