Fidgetin-like 2 (FL2) is an enzyme which in humans is encoded by the gene FIGNL2. FL2 slows the rate at which skin cells migrate to wounds to heal them. If this enzyme is suppressed/absent, skin cells move faster, speeding the healing process.[5] FL2 is closely related to another protein called fidgetin (encoded by FIGN in humans), which severs microtubules.[5]
Delivery
Molecules of silencing RNA (siRNA) that bind to a gene's messenger RNA (mRNA) can inhibit the production of FL2, but siRNAs require protection from degradation in order to reach a wound site.[6]
In 2015, researchers disclosed the successful use of nanoparticles to ferry siRNA molecules to their intended targets, reducing healing times in mice with skin excisions or burns. The result was normal, well-orchestrated tissue, including hair follicles and supportive collagen network.[5][6]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000261308 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000095440 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 3 Charafeddine RA, Makdisi J, Schairer D, O'Rourke BP, Diaz-Valencia JD, Chouake J, et al. (September 2015). "Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing". The Journal of Investigative Dermatology. 135 (9): 2309–2318. doi:10.1038/jid.2015.94. PMC 4537388. PMID 25756798.
- 1 2 Moss R (March 30, 2015). "Nanoparticles help wounds to heal 50 percent faster". Gizmag. Retrieved 3 April 2015.
