FBLIM1

FBLIM1
Identifiers
Aliases	FBLIM1, CAL, FBLP-1, FBLP1, filamin binding LIM protein 1
External IDs	OMIM: 607747; MGI: 1921452; GeneCards: FBLIM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K9U, 2W0P, 4P3W
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.21 Start 15,756,607 bp End 15,786,594 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D3 Start 141,303,373 bp End 141,333,407 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery Descending thoracic aorta ascending aorta mucosa of ileum popliteal artery tibial arteries cardiac muscle tissue of right atrium saphenous vein pancreatic ductal cell left coronary artery Top expressed in interventricular septum ascending aorta tunica media of zone of aorta aortic valve myocardium of ventricle right ventricle genital tubercle cardiac muscles epithelium of stomach left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function filamin binding protein binding metal ion binding Cellular component cytoplasm cytosol cell cortex cytoskeleton stress fiber focal adhesion fibrillar center cell junction Biological process regulation of integrin activation cell adhesion cell junction assembly regulation of cell shape cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 54751 74202 Ensembl ENSG00000162458 ENSMUSG00000006219 UniProt Q8WUP2 Q71FD7 RefSeq (mRNA) NM_001024215 NM_001024216 NM_017556 NM_001350151 NM_001163256 NM_133754 NM_001378958 NM_001378959 RefSeq (protein) NP_001019386 NP_001019387 NP_060026 NP_001337080 NP_001156728 NP_598515 NP_001365887 NP_001365888 NP_001391569 NP_001391570 NP_001391571 NP_001391572 NP_001391573 Location (UCSC) Chr 1: 15.76 – 15.79 Mb Chr 4: 141.3 – 141.33 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.

This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.

Interactions

FBLIM1 has been shown to interact with filamin, PLEKHC1 and FLNB.

Further reading

• Wu C (2005). "Migfilin and its binding partners: from cell biology to human diseases". J. Cell Sci. 118 (Pt 4): 659–64. doi:10.1242/jcs.01639. PMID 15701922. S2CID 14289176.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Akazawa H, Kudoh S, Mochizuki N, Takekoshi N, Takano H, Nagai T, Komuro I (2004). "A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5". J. Cell Biol. 164 (3): 395–405. doi:10.1083/jcb.200309159. PMC 2172236. PMID 14757752.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gkretsi V, Zhang Y, Tu Y, Chen K, Stolz DB, Yang Y, Watkins SC, Wu C (2005). "Physical and functional association of migfilin with cell-cell adhesions". J. Cell Sci. 118 (Pt 4): 697–710. doi:10.1242/jcs.01638. PMID 15671069.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Zhang Y, Tu Y, Gkretsi V, Wu C (2006). "Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration". J. Biol. Chem. 281 (18): 12397–407. doi:10.1074/jbc.M512107200. PMID 16531412.
• Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Papachristou DJ, Gkretsi V, Tu Y, Shi X, Chen K, Larjava H, Rao UN, Wu C (2007). "Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma". Histopathology. 51 (4): 499–508. doi:10.1111/j.1365-2559.2007.02791.x. PMC 2768333. PMID 17711449.