Estradiol 17beta-dehydrogenase
| estradiol 17-beta-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.62 | ||||||||
| CAS no. | 9028-61-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an estradiol 17beta-dehydrogenase (EC 1.1.1.62) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are estradiol and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are estrone, reduced NADH, and a proton. The enzyme can alternatively use nicotinamide adenine dinucleotide phosphate as its cofactor.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is estradiol-17beta:NAD(P)+ 17-oxidoreductase. Other names in common use include 20alpha-hydroxysteroid dehydrogenase, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.
Structural studies
As of late 2007, 29 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1A27, PDB: 1BHS, PDB: 1DHT, PDB: 1EQU, PDB: 1FDS, PDB: 1FDT, PDB: 1FDU, PDB: 1FDV, PDB: 1FDW, PDB: 1GZ6, PDB: 1I5R, PDB: 1IKT, PDB: 1IOL, PDB: 1JTV, PDB: 1QYV, PDB: 1QYW, PDB: 1QYX, PDB: 1S1P, PDB: 1S1R, PDB: 1S2A, PDB: 1S2C, PDB: 1XF0, PDB: 1YB1, PDB: 1ZQ5, PDB: 2F38, PDB: 2FGB, PDB: 2HQ1, PDB: 2PD6, and PDB: 3DHE.
References
- ↑ Enzyme 1.1.1.62 at KEGG Pathway Database.
- ↑ Kautsky MP, Hagerman DD (1970). "17β-Estradiol Dehydrogenase of Ovine Ovaries". J. Biol. Chem. 245 (8): 1978–84. doi:10.1016/S0021-9258(18)63194-1. PMID 4314937.
- ↑ Langer LJ, Alexander JA, Engel LL (1959). "Human Placental Estradiol-17β Dehydrogenase. II. Kinetics and substrate specificities". J. Biol. Chem. 234 (10): 2609–14. doi:10.1016/S0021-9258(18)69746-7. PMID 14413943.