Epsametostat

Epsametostat
Clinical data
Other namesHH2853
Identifiers
  • N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-6-methyl-1-(6-methylpyridazin-3-yl)-5-[(1R)-1-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]ethyl]indolizine-7-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC31H36F3N7O3
Molar mass611.670 g·mol−1
3D model (JSmol)
  • CC1=NN=C(C=C1)C2=C3C=C(C(=C(N3C=C2)[C@@H](C)N4CCN(CC4)CC(F)(F)F)C)C(=O)NCC5=C(C=C(NC5=O)C)OC
  • InChI=InChI=1S/C31H36F3N7O3/c1-18-6-7-25(38-37-18)22-8-9-41-26(22)15-23(29(42)35-16-24-27(44-5)14-19(2)36-30(24)43)20(3)28(41)21(4)40-12-10-39(11-13-40)17-31(32,33)34/h6-9,14-15,21H,10-13,16-17H2,1-5H3,(H,35,42)(H,36,43)/t21-/m1/s1
  • Key:BIABSPVTTUDBEO-OAQYLSRUSA-N

Epsametostat is an investigational new drug that is being evaluated for the treatment of peripheral T-cell lymphoma. It is a EZH1/EZH2 inhibitor developed by Shanghai Haihe Pharmaceutical Research & Development Co., Ltd.[1][2][3]

References

  1. ↑ An R, Li YQ, Lin YL, Xu F, Li MM, Liu Z (February 2023). "EZH1/2 as targets for cancer therapy". Cancer Gene Therapy. 30 (2): 221–235. doi:10.1038/s41417-022-00555-1. PMID 36369341.
  2. ↑ Wei L, Mei D, Hu S, Du S (August 2024). "Dual-target EZH2 inhibitor: latest advances in medicinal chemistry". Future Medicinal Chemistry. 16 (15): 1561–1582. doi:10.1080/17568919.2024.2380243. PMC 11370917. PMID 39082677.
  3. ↑ "Epsametostat". PatSnap.
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