Endothelin converting enzyme 1

ECE1
Identifiers
Aliases	ECE1, ECE, endothelin converting enzyme 1
External IDs	OMIM: 600423; MGI: 1101357; GeneCards: ECE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DWB
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	21,345,572 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,692,540 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; left adrenal cortex; ; right adrenal gland; ; popliteal artery; ; tibial arteries; ; right adrenal cortex; ; right lung; ; right coronary artery; ; gastric mucosa; ; canal of the cervix;
	Top expressed in
	aortic valve; ; right lung lobe; ; endothelial cell of lymphatic vessel; ; ascending aorta; ; islet of Langerhans; ; gastrula; ; lip; ; pituitary gland; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; metal ion binding; peptide hormone binding; peptidase activity; protein binding; hydrolase activity; metallopeptidase activity; protein homodimerization activity; metalloendopeptidase activity; zinc ion binding;
Cellular component	Weibel-Palade body; integral component of membrane; vesicle; endosome; membrane; lysosomal membrane; intrinsic component of endosome membrane; perinuclear region of cytoplasm; extracellular exosome; external side of plasma membrane; early endosome; plasma membrane;
Biological process	endothelin maturation; bradykinin catabolic process; regulation of systemic arterial blood pressure by endothelin; embryonic digit morphogenesis; ear development; hormone catabolic process; proteolysis; development of the heart; calcitonin catabolic process; regulation of vasoconstriction; substance P catabolic process; pharyngeal system development; positive regulation of receptor recycling; protein processing; peptide hormone processing;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1889
	230857
	ENSG00000117298
	ENSMUSG00000057530
	P42892
	Q4PZA2
	NM_001113347; NM_001113348; NM_001113349; NM_001397
	NM_199307; NM_001369177; NM_001369178; NM_001369179
	NP_001106818; NP_001106819; NP_001106820; NP_001388; NP_001106820.1
	NP_955011; NP_001356106; NP_001356107; NP_001356108
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.^[5]^[6]^[7] It is inhibited by phosphoramidon.^[8] ECE1 also mediates melanin production through breaking down inactive Big-EDN1 to produce an active EDN1 in keratinocytes and endothelial cells. ^[9]

Function

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117298 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057530 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ECE1 endothelin converting enzyme 1".
↑ Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, et al. (December 1994). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Letters. 356 (2–3): 238–243. doi:10.1016/0014-5793(94)01277-6. PMID 7805846.
↑ Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, et al. (February 1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochemical and Biophysical Research Communications. 207 (2): 807–812. doi:10.1006/bbrc.1995.1258. PMID 7864876.
↑ Schulz H, Dale GE, Karimi-Nejad Y, Oefner C (January 2009). "Structure of human endothelin-converting enzyme I complexed with phosphoramidon". Journal of Molecular Biology. 385 (1): 178–187. doi:10.1016/j.jmb.2008.10.052. PMID 18992253.
↑ Park PJ, Lee TR, Cho EG (February 2015). "Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes". The Journal of Investigative Dermatology. 135 (2): 551–559. doi:10.1038/jid.2014.423. PMID 25268585.

Yorimitsu K, Moroi K, Inagaki N, Saito T, Masuda Y, Masaki T, et al. (March 1995). "Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2". Biochemical and Biophysical Research Communications. 208 (2): 721–727. doi:10.1006/bbrc.1995.1397. PMID 7695628.
Valdenaire O, Rohrbacher E, Mattei MG (1996). "Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)". The Journal of Biological Chemistry. 270 (50): 29794–29798. doi:10.1074/jbc.270.50.29794. PMID 8530372.
Matsuoka R, Sawamura T, Yamada K, Yoshida M, Furutani Y, Ikura T, et al. (1996). "Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1". Cytogenetics and Cell Genetics. 72 (4): 322–324. doi:10.1159/000134214. PMID 8641140.
Orzechowski HD, Richter CM, Funke-Kaiser H, Kröger B, Schmidt M, Menzel S, et al. (July 1997). "Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells". Journal of Molecular Medicine. 75 (7). Berlin, Germany: 512–521. doi:10.1007/s001090050136. PMID 9253714. S2CID 34633812.
Schweizer A, Valdenaire O, Nelböck P, Deuschle U, Dumas Milne Edwards JB, Stumpf JG, et al. (December 1997). "Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations". The Biochemical Journal. 328 ( Pt 3) (Pt 3): 871–877. doi:10.1042/bj3280871. PMC 1218999. PMID 9396733.
Kido T, Sawamura T, Masaki T (1998). "The processing pathway of endothelin-1 production". Journal of Cardiovascular Pharmacology. 31 (Suppl 1): S13–5. doi:10.1097/00005344-199800001-00006. PMID 9595387.
Hofstra RM, Valdenaire O, Arch E, Osinga J, Kroes H, Löffler BM, et al. (January 1999). "A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction". American Journal of Human Genetics. 64 (1): 304–308. doi:10.1086/302184. PMC 1377732. PMID 9915973.
Lee S, Lin M, Mele A, Cao Y, Farmar J, Russo D, et al. (August 1999). "Proteolytic processing of big endothelin-3 by the kell blood group protein". Blood. 94 (4): 1440–1450. doi:10.1182/blood.V94.4.1440. PMID 10438732.
Valdenaire O, Lepailleur-Enouf D, Egidy G, Thouard A, Barret A, Vranckx R, et al. (September 1999). "A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization". European Journal of Biochemistry. 264 (2): 341–349. doi:10.1046/j.1432-1327.1999.00602.x. PMID 10491078.
Fahnoe DC, Johnson GD, Herman SB, Ahn K (2000). "Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells". Archives of Biochemistry and Biophysics. 373 (2): 385–393. doi:10.1006/abbi.1999.1586. PMID 10620363.
López-Ongil S, Senchak V, Saura M, Zaragoza C, Ames M, Ballermann B, et al. (August 2000). "Superoxide regulation of endothelin-converting enzyme". The Journal of Biological Chemistry. 275 (34): 26423–26427. doi:10.1074/jbc.M000767200. PMID 10833511.
Hachiya A, Kobayashi T, Takema Y, Imokawa G (2002). "Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis". The Journal of Biological Chemistry. 277 (7): 5395–5403. doi:10.1074/jbc.M105874200. PMID 11723113.
Inguimbert N, Coric P, Poras H, Meudal H, Teffot F, Fournié-Zaluski MC, et al. (March 2002). "Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP)". Journal of Medicinal Chemistry. 45 (7): 1477–1486. doi:10.1021/jm0005454. PMID 11906289.
MacLeod KJ, Husain RD, Gage DA, Ahn K (2003). "Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms". The Journal of Biological Chemistry. 277 (48): 46355–46363. doi:10.1074/jbc.M207972200. PMID 12244060.
Muller L, Barret A, Etienne E, Meidan R, Valdenaire O, Corvol P, et al. (January 2003). "Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease". The Journal of Biological Chemistry. 278 (1): 545–555. doi:10.1074/jbc.M208949200. PMID 12393864.
Eckman EA, Watson M, Marlow L, Sambamurti K, Eckman CB (January 2003). "Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme". The Journal of Biological Chemistry. 278 (4): 2081–2084. doi:10.1074/jbc.C200642200. PMID 12464614.
Masatsugu K, Itoh H, Chun TH, Saito T, Yamashita J, Doi K, et al. (March 2003). "Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress". Regulatory Peptides. 111 (1–3): 13–19. doi:10.1016/S0167-0115(02)00219-7. hdl:2433/147555. PMID 12609744. S2CID 37039969.
Smollich M, Götte M, Yip GW, Yong ES, Kersting C, Fischgräbe J, et al. (December 2007). "On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer". Breast Cancer Research and Treatment. 106 (3): 361–369. doi:10.1007/s10549-007-9516-9. PMID 17295044. S2CID 5546294.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117298 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057530 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ECE1 endothelin converting enzyme 1".

[Schmidt_1994-6] Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, et al. (December 1994). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Letters. 356 (2–3): 238–243. doi:10.1016/0014-5793(94)01277-6. PMID 7805846.

[Shimada_1995-7] Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, et al. (February 1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochemical and Biophysical Research Communications. 207 (2): 807–812. doi:10.1006/bbrc.1995.1258. PMID 7864876.

[8] Schulz H, Dale GE, Karimi-Nejad Y, Oefner C (January 2009). "Structure of human endothelin-converting enzyme I complexed with phosphoramidon". Journal of Molecular Biology. 385 (1): 178–187. doi:10.1016/j.jmb.2008.10.052. PMID 18992253.

[9] Park PJ, Lee TR, Cho EG (February 2015). "Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes". The Journal of Investigative Dermatology. 135 (2): 551–559. doi:10.1038/jid.2014.423. PMID 25268585.

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Function

References

Further reading