Endoglycosylceramidase
| endoglycosylceramidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.2.1.123 | ||||||||
| CAS no. | 105503-61-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme endoglycosylceramidase (EC 3.2.1.123) catalyzes the following chemical reaction:
- oligoglycosylglucosylceramide + H2O ceramide + oligoglycosylglucose
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name is oligoglycosylglucosylceramide glycohydrolase. Other names in common use include endoglycoceramidase, EGCase, and glycosyl-N-acetyl-sphingosine 1,1-β-D-glucanohydrolase.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB: 2OSW, PDB: 2OSX, PDB: 2OSY, PDB: 2OYK, PDB: 2OYL, and PDB: 2OYM.
References
- Ito M, Yamagata T (1986). "A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids". J. Biol. Chem. 261 (30): 14278–82. doi:10.1016/S0021-9258(18)67015-2. PMID 3771534.
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