Emma Guttman-Yassky

Emma Guttman-Yassky
OccupationsSystem Chair, Department of Dermatology, and the Waldman professor of dermatology and immunology, at the Icahn School of Medicine at Mount Sinai in New York.
Academic background
Education
Academic work
Disciplinedermatology, immunology
Sub-discipline
inflammatory skin disease
InstitutionsIcahn School of Medicine at Mount Sinai
Websiteprofiles.mountsinai.org/emma-guttman

Emma Guttman-Yassky is the System Chair of the Department of Dermatology and Waldman professor of dermatology and immunology at the Icahn School of Medicine at Mount Sinai in New York.[1] She is also director of the Asness Family Center for Excellence in Eczema, Mount Sinai Clinique Healthy Skin Dermatology Center and its Inflammatory Skin Disease Laboratory.[2][3]

According to Google Scholar she has an h-index of 124.[4]

Education

Guttman received her MD from Sackler School of Medicine in 1996. While completing her dermatology residency at the Rambam Medical Center, she pursued postgraduate studies in dermatology and basic sciences at the Sackler Faculty of Medicine. She went on to study internal medicine during her translational year at Memorial Sloan-Kettering Cancer Center in 2008. Before completing her dermatology residency at Weill Cornell Medical College in 2011, she also received her PhD in 2010 for her thesis on clinical and molecular aspects of Classic Kaposi's Sarcoma at Bar-Ilan University.

Research

Dr. Guttman's research made breakthrough discoveries on the immunologic basis of atopic dermatitis/eczema (AD) and alopecia areata (AA) as well as scarring alopecia. She is the first to identify in humans a distinct population of T-cells that independently produce IL-22 without co-producing IL-17 (as in mice), framing the concept that in humans, Th22 T-cells are distinct from Th17 T-cells.[5] Guttman has also designed a clinical trial that was funded by the NIH/NIAMS (UM1AR063917-01), utilizing an anti-IL-22 antibody - the first to explore the biological effects of blocking IL-22 on AD.[6] Additionally, she established the reversibility of AD and defined a series of therapeutic response-biomarkers that are now implemented in testing of novel therapeutics.

Dr. Guttman's research identified that different AD subsets (intrinsic/extrinsic, pediatric/adult, and differences between AD patients from different racial/ethnic backgrounds) differ in their immune polarization, enabling a personalized medicine approach.[7][8] Her lab is currently studying the contribution of specific Th2-, Th17/IL-23-, and Th22-targeting treatments to different AD phenotypes.[2]

More recently, her studies extended to other inflammatory skin diseases (alopecia areata/AA and contact dermatitis), where they have also made significant observations. They have shown that human allergic contact dermatitis is not a single entity, and various allergens (i.e., nickel, fragrance) induce differential immune polarizations.[9] They have also redefined the molecular maps of AA, associating its molecular profile with Th1/IFN, Th2, and IL-23 activation.[10] They initiated clinical trials with specific (dupilumab, targeting only the Th2 immune pathway) or broad agents that are now identifying which cytokine pathways are pathogenic in AA.

Awards and Honors

Since she became the system chair Mount Sinai dermatology in 2021, Dr. Guttman has helped skyrocket the department's NIH funding from less than $500,000 to nearly $39.5 million to date.[11] In acknowledgement of the impact of Dr. Guttman's observations on translational medicine, she has received numerous awards over the years.

  • 2026 Elected to the Association of American Physicians (AAP)[12][13]
  • The 2024 European Academy of Allergy and Clinical Immunology (EAACI) Annual Congress selected Dr. Guttman, as the recipient of the Paul Ehrlich Award for Experimental Research[14]
  • 2024 Jacobi Medallion Award[15]
  • 2021 Donald Y.M. Leung, MD, PhD, FAAAAI-JACI Editors Lectureship and Faculty Development Award: Dr. Guttman's presented lecture topic, Emerging Biologics in the Treatment of Atopic Dermatitis[16]
  • 2021 Dermatitis Article of the Year Award[17][18]
  • 2019 Bettina C. Hilman Award for “the pioneer contribution to science and impact on patient’s lives”[19]
  • 2018 co-founder, Director, and Elected President of the International Eczema Council[20]
  • Elected as board member for the American Skin Association (ASA)[21]
  • 2011 American Academy of Dermatology Young Investigator Award[22]

References

  1. ↑ "Emma Guttman - Dermatology". Mount Sinai Health System. Retrieved 12 March 2023.
  2. 1 2 "Laboratory of Inflammatory Skin Diseases". Laboratory of Inflammatory Skin Diseases |. Retrieved 12 March 2023.
  3. ↑ "Mount Sinai to Receive $5 Million Gift From the Asness Family to Advance Eczema and Allergy Research and Treatment". 30 June 2025.
  4. ↑ "Emma Guttman-Yassky". Google Scholar.
  5. ↑ Nograles, Kristine E.; Zaba, Lisa C.; Shemer, Avner; Fuentes-Duculan, Judilyn; Cardinale, Irma; Kikuchi, Toyoko; Ramon, Michal; Bergman, Reuven; Krueger, James G.; Guttman-Yassky, Emma (1 June 2009). "IL-22–producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells". Journal of Allergy and Clinical Immunology. 123 (6): 1244–1252.e2. doi:10.1016/j.jaci.2009.03.041. PMC 2874584. PMID 19439349.
  6. ↑ Guttman-Yassky, Emma; Brunner, Patrick M.; Neumann, Avidan U.; Khattri, Saakshi; Pavel, Ana B.; Malik, Kunal; Singer, Giselle K.; Baum, Danielle; Gilleaudeau, Patricia; Sullivan-Whalen, Mary; Rose, Sharon; Jim On, Shelbi; Li, Xuan; Fuentes-Duculan, Judilyn; Estrada, Yeriel (1 May 2018). "Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial". Journal of the American Academy of Dermatology. 78 (5): 872–881.e6. doi:10.1016/j.jaad.2018.01.016. PMC 8711034. PMID 29353025.
  7. ↑ Silverberg, Jonathan I.; Guttman-Yassky, Emma; Thaçi, Diamant; Irvine, Alan D.; Stein Gold, Linda; Blauvelt, Andrew; Simpson, Eric L.; Chu, Chia-Yu; Liu, Zhuqing; Gontijo Lima, Renata; Pillai, Sreekumar G.; Seneschal, Julien (23 March 2023). "Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis". New England Journal of Medicine. 388 (12): 1080–1091. doi:10.1056/NEJMoa2206714. ISSN 0028-4793. PMID 36920778.
  8. ↑ Guttman-Yassky, Emma; Simpson, Eric L; Reich, Kristian; Kabashima, Kenji; Igawa, Ken; Suzuki, Tetsuya; Mano, Hirotaka; Matsui, Takeshi; Esfandiari, Ehsanollah; Furue, Masutaka (9 December 2022). "An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis: a multicentre, double-blind, placebo-controlled phase 2b study". The Lancet. 401 (10372): 204–214. doi:10.1016/S0140-6736(22)02037-2. PMID 36509097.
  9. ↑ Dhingra, Nikhil; Shemer, Avner; Correa da Rosa, Joel; Rozenblit, Mariya; Fuentes-Duculan, Judilyn; Gittler, Julia K.; Finney, Robert; Czarnowicki, Tali; Zheng, Xiuzhong; Xu, Hui; Estrada, Yeriel D.; Cardinale, Irma; Suárez-Fariñas, Mayte; Krueger, James G.; Guttman-Yassky, Emma (1 August 2014). "Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response". Journal of Allergy and Clinical Immunology. 134 (2): 362–372. doi:10.1016/j.jaci.2014.03.009. PMID 24768652.
  10. ↑ Suárez-Fariñas, Mayte; Ungar, Benjamin; Noda, Shinji; Shroff, Anjali; Mansouri, Yasaman; Fuentes-Duculan, Judilyn; Czernik, Annette; Zheng, Xiuzhong; Estrada, Yeriel D.; Xu, Hui; Peng, Xiangyu; Shemer, Avner; Krueger, James G.; Lebwohl, Mark G.; Guttman-Yassky, Emma (1 November 2015). "Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing". Journal of Allergy and Clinical Immunology. 136 (5): 1277–1287. doi:10.1016/j.jaci.2015.06.032. PMID 26316095.
  11. ↑ "Message from the Chair". reports.mountsinai.org. Retrieved 21 July 2026.
  12. ↑ Mann, Denise (25 April 2026). "Dr. Emma Guttman Elected to the Association of American Physicians". The Dermatology Digest. Retrieved 21 July 2026.
  13. ↑ "Mount Sinai's Emma Guttman, MD, PhD, Elected to the Association of American Physicians | Mount Sinai - New York". Mount Sinai Health System. Retrieved 21 July 2026.
  14. ↑ "Emma Guttman-Yassky, MD, PhD, Receives High Honor at European Academy of Allergy and Clinical Immunology | Mount Sinai - New York". Mount Sinai Health System. Retrieved 21 July 2026.
  15. ↑ Schwab, David (23 March 2024). "2024 Jacobi Medallion Award Ceremony | Mount Sinai Today". Mount Sinai Today. Archived from the original on 13 February 2026. Retrieved 21 July 2026.
  16. ↑ "Donald Y.M. Leung, MD, PhD, FAAAAI-JACI Editors Lectureship and Faculty Development Award | AAAAIFoundation.org". www.aaaaifoundation.org. Retrieved 21 July 2026.
  17. ↑ "Award History | American Contact Dermatitis Society (ACDS)". American Contact Dermatitis Society. Retrieved 21 July 2026.
  18. ↑ Mikhaylov, Daniela; Del Duca, Ester; Olesen, Caroline Meyer; He, Helen; Wu, Jianni; Ungar, Benjamin; Estrada, Yeriel; Zhang, Ning; Chowdhury, Mashkura; Clausen, Maja-Lisa; Krueger, James G.; Pavel, Ana B.; Agner, Tove; Guttman-Yassky, Emma (1 October 2021). "Transcriptomic Profiling of Tape-Strips From Moderate to Severe Atopic Dermatitis Patients Treated With Dupilumab". Dermatitis: Contact, Atopic, Occupational, Drug. 32 (1S): S71–S80. doi:10.1097/DER.0000000000000764. ISSN 2162-5220. PMID 34405829.
  19. ↑ "Annual Reports | AAAAIFoundation.org". www.aaaaifoundation.org. Retrieved 21 July 2026.
  20. ↑ "Board of Directors". www.eczemacouncil.org. Retrieved 21 July 2026.
  21. ↑ "Board of Directors | American Skin Association". www.americanskin.org. Retrieved 21 July 2026.
  22. ↑ "Young Investigator Awards". www.aad.org. Retrieved 21 July 2026.
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