Ectonucleoside triphosphate diphosphohydrolase 7

ENTPD7
Identifiers
Aliases	ENTPD7, LALP1, ectonucleoside triphosphate diphosphohydrolase 7
External IDs	OMIM: 616753; MGI: 2135885; GeneCards: ENTPD7
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	99,711,241 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	43,722,136 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; buccal mucosa cell; ; duodenum; ; mucosa of ileum; ; sperm; ; secondary oocyte; ; cartilage tissue; ; stromal cell of endometrium; ; mucosa of sigmoid colon; ; testicle;
	Top expressed in
	jejunum; ; pyloric antrum; ; duodenum; ; intestinal epithelium; ; cumulus cell; ; gastrula; ; epithelium of small intestine; ; motor neuron; ; intestinal villus; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; metal ion binding; nucleoside-triphosphatase activity;
Cellular component	integral component of membrane; cytoplasmic vesicle membrane; membrane; cytoplasmic vesicle; endocytic vesicle membrane;
Biological process	nucleobase-containing small molecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57089
	93685
	ENSG00000198018
	ENSMUSG00000025192
	Q9NQZ7
	Q3TCT4
	NM_020354; NM_001349962; NM_001349963
	NM_053103
	NP_065087; NP_001336891; NP_001336892
	NP_444333
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 7 is a protein that in humans is encoded by the ENTPD7 gene.^[5]

Function

This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017].

1 2 3 GRCh38: Ensembl release 89: ENSG00000198018 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025192 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Ectonucleoside triphosphate diphosphohydrolase 7". Retrieved 2018-05-11.