ELM2 domain

ELM2 domain
Identifiers
SymbolELM2
InterProIPR000949
PROSITEPDOC51156
Available protein structures:
PDB  IPR000949  
AlphaFold

The ELM2 domain is a protein motif found in transcriptional corepressors such as CoREST and MTA1. The name ELM2 is an acronym standing for Egl-27 and MTA1 homology 2.[1] This domain helps recruit HDAC proteins to corepression complexes to further down regulate gene expression by making chromatin less accessible through deacetylating of histones.[2]

References

  1. ↑ Millard CJ, Fairall L, Schwabe JW (December 2014). "Towards an understanding of the structure and function of MTA1". Cancer Metastasis Reviews. 33 (4): 857–867. doi:10.1007/s10555-014-9513-5. PMC 4244562. PMID 25352341.
  2. ↑ Ding Z, Gillespie LL, Paterno GD (January 2003). "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain". Molecular and Cellular Biology. 23 (1): 250–258. doi:10.1128/MCB.23.1.250-258.2003. PMC 140656. PMID 12482978.
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