Glutamine—fructose-6-phosphate transaminase (isomerizing)
| Glutamine-fructose-6-phosphate transaminase (isomerizing) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Glutamine—fructose-6-phosphate transaminase 1, homodimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 2.6.1.16 | ||||||||
| CAS no. | 9030-45-9 | ||||||||
| Alt. names |
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| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Glutamine-fructose-6-phosphate transaminase (isomerizing) sometimes called glucosaminephosphate isomerase (EC 2.6.1.16) is an enzyme that catalyzes the chemical reaction:[1]
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The two substrates of this enzyme first characterised from Neurospora crassa are L-glutamine and D-fructose 6-phosphate (shown in its open-chain ketone form). Its products are L-glutamic acid and D-glucosamine 6-phosphate.[2]
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating).[3] This enzyme participates in glutamate metabolism and aminosugars metabolism.[4][5]
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1JXA, PDB: 1MOQ, PDB: 1MOR, PDB: 1MOS, PDB: 1XFF, PDB: 1XFG, PDB: 2BPL, PDB: 2J6H, PDB: 2POC, PDB: 2PUT, PDB: 2PUV, and PDB: 2PUW.
References
- ↑ Teplyakov A, Obmolova G, Badet-Denisot MA, Badet B (1999). "The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase". Protein Sci. 8 (3): 596–602. doi:10.1110/ps.8.3.596. PMC 2144271. PMID 10091662.
- ↑ Leloir LF, Cardini CE (1953). "The biosynthesis of glucosamine". Biochim. Biophys. Acta. 12 (1–2): 15–22. doi:10.1016/0006-3002(53)90119-X. hdl:11336/140740. PMID 13115409.
- ↑ Enzyme 2.6.1.16 at KEGG Pathway Database.
- ↑ Ghosh S, Blumenthal HJ, Davidson E, Roseman S (1960). "Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate". J. Biol. Chem. 235 (5): 1265–73. doi:10.1016/S0021-9258(18)69397-4. PMID 13827775.
- ↑ Gryder RM, Pogell BM (1960). "Further studies on glucosamine 6-phosphate synthesis by rat liver enzymes". J. Biol. Chem. 235 (3): 558–62. doi:10.1016/S0021-9258(19)67904-4. PMID 13829889.