E74 like ETS transcription factor 3

ELF3
Identifiers
Aliases	ELF3, EPR-1, ERT, ESE-1, ESX, E74 like ETS transcription factor 3
External IDs	OMIM: 602191; MGI: 1101781; GeneCards: ELF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E8P
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,017,183 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,186,306 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; rectum; ; pancreatic ductal cell; ; gallbladder; ; body of pancreas; ; minor salivary glands; ; islet of Langerhans; ; right uterine tube; ; palpebral conjunctiva;
	Top expressed in
	corneal stroma; ; pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; blastocyst; ; duodenum; ; colon; ; left colon; ; medulla of thymus; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; Golgi apparatus; cytosol; nucleoplasm;
Biological process	cell differentiation; regulation of transcription, DNA-templated; epithelial cell differentiation; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; extracellular matrix organization; transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; epidermis development; inflammatory response; negative regulation of transcription, DNA-templated; blastocyst development; positive regulation of transcription by RNA polymerase II; mammary gland involution; positive regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1999
	13710
	ENSG00000163435
	ENSMUSG00000003051
	P78545
	Q3UPW2
	NM_001114309; NM_004433
	NM_001163131; NM_007921
	NP_001107781; NP_004424
	NP_001156603; NP_031947
	Wikidata
View/Edit Human	View/Edit Mouse

ETS-related transcription factor Elf-3 is a protein that in humans is encoded by the ELF3 gene. It is a member of the ETS transcription factor family^[5] and was named for its homology to E74, a transcription factor from Drosophila melanogaster.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163435 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003051 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: E74 like ETS transcription factor 3". Retrieved 2018-07-16.
↑ Tymms MJ, Ng AY, Thomas RS, Schutte BC, Zhou J, Eyre HJ, Sutherland GR, Seth A, Rosenberg M, Papas T, Debouck C, Kola I (13 November 1997). "A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer". Oncogene. 15 (20): 2449–62. doi:10.1038/sj.onc.1201427. PMID 9395241.

Neve RM, Ylstra B, Chang CH, Albertson DG, Benz CC (May 2002). "ErbB2 activation of ESX gene expression". Oncogene. 21 (24): 3934–8. doi:10.1038/sj.onc.1205503. PMID 12032832.
Asada S, Choi Y, Yamada M, Wang SC, Hung MC, Qin J, Uesugi M (October 2002). "External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12747–52. Bibcode:2002PNAS...9912747A. doi:10.1073/pnas.202162199. PMC 130531. PMID 12242338.
Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC (January 2003). "ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells". J. Biol. Chem. 278 (2): 875–84. doi:10.1074/jbc.M208241200. PMID 12414801.
Cabral A, Fischer DF, Vermeij WP, Backendorf C (May 2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. hdl:1887/50054. PMID 12624109.
Lee HJ, Chang JH, Kim YS, Kim SJ, Yang HK (September 2003). "Effect of ets-related transcription factor (ERT) on transforming growth factor (TGF)-beta type II receptor gene expression in human cancer cell lines". J. Exp. Clin. Cancer Res. 22 (3): 477–80. PMID 14582709.
Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravallese EM, Oettgen P (March 2004). "ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation". J. Biol. Chem. 279 (13): 12794–803. doi:10.1074/jbc.M308593200. PMID 14715662.
Schedin PJ, Eckel-Mahan KL, McDaniel SM, Prescott JD, Brodsky KS, Tentler JJ, Gutierrez-Hartmann A (March 2004). "ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells". Oncogene. 23 (9): 1766–79. doi:10.1038/sj.onc.1207391. PMID 14767472.
Wang H, Fang R, Cho JY, Libermann TA, Oettgen P (June 2004). "Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86". J. Biol. Chem. 279 (24): 25241–50. doi:10.1074/jbc.M401356200. PMID 15075319.
Prescott JD, Koto KS, Singh M, Gutierrez-Hartmann A (June 2004). "The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism". Mol. Cell. Biol. 24 (12): 5548–64. doi:10.1128/MCB.24.12.5548-5564.2004. PMC 419891. PMID 15169914.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163435 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003051 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: E74 like ETS transcription factor 3". Retrieved 2018-07-16.

[6] Tymms MJ, Ng AY, Thomas RS, Schutte BC, Zhou J, Eyre HJ, Sutherland GR, Seth A, Rosenberg M, Papas T, Debouck C, Kola I (13 November 1997). "A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer". Oncogene. 15 (20): 2449–62. doi:10.1038/sj.onc.1201427. PMID 9395241.

[1]

[2]

[3]

[4]

[5]

[6]

References

Further reading