Dystrophin-associated protein

A dystrophin-associated protein is a protein that helps to form the connection between intracellular dystrophin and the extracellular basal lamina.

Examples include sarcoglycan and dystroglycan.[1]

Dystrophin-associated proteins contribute to mechanical stabilization of the muscle-cell membrane during contraction, and loss of these proteins may increase plasma membrane fragility.[2] Because of its role in muscle-cell stability, the dystrophin-associated protein complex has been studied using mass spectrometry to identify protein interactors, analyze post-translational glycan modifications of α-dystroglycan, and measure dystrophin levels in healthy and dystrophic skeletal muscle.[3]

References

  1. ↑ Dystrophin-Associated Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  2. ↑ Kaplan, Katherine M.; Morgan, Kathleen G. (2022). "The importance of dystrophin and the dystrophin associated proteins in vascular smooth muscle". Frontiers in Physiology. 13 1059021. doi:10.3389/fphys.2022.1059021. PMC 9732661. PMID 36505053.
  3. ↑ Canessa, E. H. (2024). "Characterization of the dystrophin-associated protein complex by mass spectrometry". Mass Spectrometry Reviews. 43 (1): 90–105. Bibcode:2024MSRv...43...90C. doi:10.1002/mas.21823. PMID 36420714.


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