Douglas C. Rees

Douglas C. Rees
Alma mater
Scientific career
Fields
Workplaces
ThesisCrystal Structure of the Potato Inhibitor Complex of Carboxypeptidase A (1980)
William Lipscomb
Other academic advisors
  • James Bryant Howard
Doctoral students
Judith Su
Websitewww.br.caltech.edu/reesgrp

Douglas Charles "Doug" Rees (born 1952) is an American biochemist, biophysicist, and structural biologist.[1]

Academic career

Rees graduated from Yale University with a bachelor's degree in 1974 working with Carolyn Slayman and received a PhD in biophysics from Harvard University in 1980.[2][3] He subsequently completed a postdoctoral fellowshing with James B. Howard at the University of Minnesota[4]. In 1982 he went to the University of California, Los Angeles.[2] In 1989, he became a professor of chemistry at Caltech.[2] There he is Roscoe Gilkey Dickinson Professor and was Dean of graduate studies from 2015-2020.[5] From 1997 to 2025, he was an investigator of the Howard Hughes Medical Institute[6]. He served as the editor or co-editor of the Annual Review of Biophysics and Biomolecular Structure (2004–2014).[7][8]

Scientific interests

He examines the structure and function of metal-containing and membrane proteins,[5] especially nitrogenase in biological nitrogen fixation,[9][10] and membrane proteins including ABC transporters and mechanosensitive ion channels including MscL[11][12] and MscS[13]. To do this, his group uses X-ray crystallography. His interest in nitrogenase began in William Lipscomb's laboratory.

Recognition

In 2015 he received the FA Cotton Medal[14], and in 2020 he was awarded the Gregori Aminoff Prize[15]. He is a member of the American Academy of Arts and Sciences[16], National Academy of Sciences[17], and was a Sloan Research Fellow.

Personal

Rees grew up in Lexington, Kentucky where his father was a faculty member in the University of Kentucky College of Medicine[18]

References

  1. ↑ Douglas C. Rees publications from Europe PubMed Central
  2. 1 2 3 "Douglas C Rees, PhD". The Vallee Foundation. Retrieved 14 April 2026.
  3. ↑ Kalte, Pamela; Nemeh, Katherine (2004). American men & women of science: a biographical directory of today's leaders in physical, biological and related sciences (21. ed.). Detroit: Gale Group. ISBN 0787665231.
  4. ↑ "Hageman Distinguished Lecturer in Agricultural Biochemistry". Department of Biochemistry and Molecular Biophysics. Kansas State University. Retrieved 14 April 2026.
  5. 1 2 "Douglas C. (Doug) Rees". Caltech. Retrieved 14 April 2026.
  6. ↑ "Douglas C. Rees, PhD". HHMI. Howard Hughes Medical Institute. Retrieved 14 April 2026.
  7. ↑ Rees, Douglas C. (2004). "Preface by Douglas C. Rees". Annual Review of Biophysics and Biomolecular Structure. 33. doi:10.1146/annurev.bb.33.051304.100011.
  8. ↑ Rees, Douglas C. (2012). "Preface". Annual Review of Biophysics. 41. doi:10.1146/annurev-bb-41-050712-100001.
  9. ↑ Howard, James B.; Rees, Douglas C. (1 January 1996). "Structural Basis of Biological Nitrogen Fixation". Chemical Reviews. 96 (7): 2965–2982. doi:10.1021/cr9500545.
  10. ↑ Einsle, Oliver; Tezcan, F. Akif; Andrade, Susana L. A.; Schmid, Benedikt; Yoshida, Mika; Howard, James B.; Rees, Douglas C. (6 September 2002). "Nitrogenase MoFe-Protein at 1.16 Å Resolution: A Central Ligand in the FeMo-Cofactor". Science. 297 (5587): 1696–1700. doi:10.1126/science.1073877.
  11. ↑ Chang, Geoffrey; Spencer, Robert H.; Lee, Allen T.; Barclay, Margaret T.; Rees, Douglas C. (18 December 1998). "Structure of the MscL Homolog from Mycobacterium tuberculosis : A Gated Mechanosensitive Ion Channel". Science. 282 (5397): 2220–2226. doi:10.1126/science.282.5397.2220.
  12. ↑ Liu, Zhenfeng; Gandhi, Chris S.; Rees, Douglas C. (September 2009). "Structure of a tetrameric MscL in an expanded intermediate state". Nature. 461 (7260): 120–124. doi:10.1038/nature08277. PMC 2737600.
  13. ↑ Bass, Randal B.; Strop, Pavel; Barclay, Margaret; Rees, Douglas C. (22 November 2002). "Crystal Structure of Escherichia coli MscS, a Voltage-Modulated and Mechanosensitive Channel". Science. 298 (5598): 1582–1587. doi:10.1126/science.1077945.
  14. ↑ Wang, Linda (9 March 2015). "Cotton Medal To Douglas Rees". C&EN. Retrieved 14 April 2026.
  15. ↑ "Studies of enzyme systems rewarded with the Aminoff Prize". IUCr Newsletter. Vol. 27, no. 4. IUCr. 18 December 2019. Retrieved 14 April 2026.
  16. ↑ "Douglas C. Rees". American Academy of Arts & Sciences. AAAS. Retrieved 14 April 2026.
  17. ↑ "Douglas C. Rees". National Academy of Sciences. NAS. Retrieved 14 April 2026.
  18. ↑ "William N. Lipscomb Centennial Celebration". William N. Lipscomb Centennial Celebration. University of Kentucky. Retrieved 14 April 2026.
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