Dimethylglycine N-methyltransferase
| Dimethylglycine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.161 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Dimethylglycine N-methyltransferase (EC 2.1.1.161, BsmB, DMT) is an enzyme with systematic name S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming).[1] This enzyme catalyses the following chemical reaction
The enzyme adds a methyl group to N.N-dimethylglycine, giving the product betaine, trimethylglycine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from the cyanobacterium, Synechococcus sp. WH8102.[2] Unlike the related enzyme, sarcosine/dimethylglycine N-methyltransferase, sarcosine is not a substrate.[1]
References
- 1 2 Enzyme 2.1.1.161 at KEGG Pathway Database.
- ↑ Lu WD, Chi ZM, Su CD (December 2006). "Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis". Archives of Microbiology. 186 (6): 495–506. Bibcode:2006ArMic.186..495L. doi:10.1007/s00203-006-0167-8. PMID 17019606. S2CID 25210214.
External links
- Dimethylglycine+N-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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