DU-125530

DU-125530
Clinical data
Other namesDU125530
Drug classSerotonin 5-HT1A receptor antagonist
ATC code
  • None
Identifiers
  • 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]butyl]-1,1-dioxo-1,2-benzothiazol-3-one
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC23H26ClN3O5S
Molar mass491.99 g·mol−1
3D model (JSmol)
  • C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=C5C(=CC(=C4)Cl)OCCO5
  • InChI=1S/C23H26ClN3O5S/c24-17-15-19(22-20(16-17)31-13-14-32-22)26-11-9-25(10-12-26)7-3-4-8-27-23(28)18-5-1-2-6-21(18)33(27,29)30/h1-2,5-6,15-16H,3-4,7-14H2
  • Key:LYXKFNHUJJDTIA-UHFFFAOYSA-N

DU-125530 is a drug which acts as a potent and selective 5-HT1A receptor antagonist. It has antidepressant effects in animal studies, as well as being used for basic research into the function of the 5-HT1A receptor.[1][2][3]

See also

References

  1. ↑ Mos J, Van Hest A, Van Drimmelen M, Herremans AH, Olivier B (May 1997). "The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons". European Journal of Pharmacology. 325 (2–3): 145–153. doi:10.1016/s0014-2999(97)00131-3. PMID 9163561.
  2. ↑ Rabiner EA, Wilkins MR, Turkheimer F, Gunn RN, Udo de Haes J, de Vries M, et al. (June 2002). "5-Hydroxytryptamine1A receptor occupancy by novel full antagonist 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: a[11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY-100635) positron emission tomography study in humans". The Journal of Pharmacology and Experimental Therapeutics. 301 (3): 1144–1150. doi:10.1124/jpet.301.3.1144. PMID 12023549.
  3. ↑ Scorza MC, Lladó-Pelfort L, Oller S, Cortés R, Puigdemont D, Portella MJ, et al. (November 2012). "Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment". British Journal of Pharmacology. 167 (5): 1021–1034. doi:10.1111/j.1476-5381.2011.01770.x. PMC 3492984. PMID 22050051.
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