DHRSX

DHRSX
Identifiers
Aliases	DHRSX, CXorf11, DHRS5X, DHRS5Y, DHRSXY, DHRSY, SDR46C1, SDR7C6, dehydrogenase/reductase (SDR family) X-linked, dehydrogenase/reductase X-linked
External IDs	MGI: 2181510; GeneCards: DHRSX
Enzyme activity
Gene location (Human)
Chr.	X chromosome (human)
End	2,502,805 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ventricular zone; ; ganglionic eminence; ; body of pancreas; ; apex of heart; ; right atrium; ; right auricle of heart; ; right lobe of liver; ; gastrocnemius muscle; ; left ventricle;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity;
Cellular component	extracellular region;
Biological process	positive regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	207063
	236082
	ENSG00000169084
	ENSMUSG00000063897
	Q8N5I4
	Q8VBZ0
	NM_145177
	NM_001033326
	NP_660160
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Dehydrogenase/reductase (SDR family) X-linked also known as DHRSX is an enzyme which in humans is encoded by the pseudoautosomal DHRSX gene.^[4] DHRSX is a member of the short-chain dehydrogenase family of oxidoreductase enzymes.^[5]

DHRSX is required for two steps in the biosynthesis of dolichol: i) the NAD⁺-dependent conversion of polyprenol to its aldehyde analogue, polyprenal; ii) the NADPH-dependent reduction of dolichal to dolichol.^[6] Dolichol is a long polyisoprenoid lipid required as the carrier of mono- and oligosaccharides in the processes of N-glycosylation, C-/O-mannosylation and the formation of glycosylphosphatidylinositol (GPI) anchors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169084 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gianfrancesco F, Sanges R, Esposito T, Tempesta S, Rao E, Rappold G, et al. (December 2001). "Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution". Genome Research. 11 (12): 2095–2100. doi:10.1101/gr.197001. PMC 311231. PMID 11731500.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
↑ Wilson MP, Kentache T, Althoff CR, Schulz C, de Bettignies G, Mateu Cabrera G, et al. (July 2024). "A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis". Cell. 187 (14): 3585–3601.e22. doi:10.1016/j.cell.2024.04.041. PMC 11250103. PMID 38821050.

Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, et al. (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, et al. (March 2008). "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169084 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11731500-4] Gianfrancesco F, Sanges R, Esposito T, Tempesta S, Rao E, Rappold G, et al. (December 2001). "Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution". Genome Research. 11 (12): 2095–2100. doi:10.1101/gr.197001. PMC 311231. PMID 11731500.

[pmid19027726-5] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[6] Wilson MP, Kentache T, Althoff CR, Schulz C, de Bettignies G, Mateu Cabrera G, et al. (July 2024). "A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis". Cell. 187 (14): 3585–3601.e22. doi:10.1016/j.cell.2024.04.041. PMC 11250103. PMID 38821050.

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References

Further reading