DDX42

DDX42
Identifiers
Aliases	DDX42, DDX42P, RHELP, RNAHP, SF3B8, SF3b125, DEAD-box helicase 42
External IDs	OMIM: 613369; MGI: 1919297; GeneCards: DDX42
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,819,317 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,249,139 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; right uterine tube; ; gastric mucosa; ; left ovary; ; right ovary; ; epithelium of colon; ; Achilles tendon; ; canal of the cervix; ; sural nerve; ; minor salivary glands;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; tail of embryo; ; neural tube; ; epiblast; ; dentate gyrus of hippocampal formation granule cell; ; lens; ; superior frontal gyrus; ; yolk sac; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; hydrolase activity; ATP binding; helicase activity; nucleic acid binding; RNA binding;
Cellular component	cytoplasm; Cajal body; membrane; nucleus; nucleoplasm; cytosol; nuclear speck; nucleolus;
Biological process	protein localization; RNA secondary structure unwinding; mRNA splicing, via spliceosome; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11325
	72047
	ENSG00000198231
	ENSMUSG00000020705
	Q86XP3
	Q810A7
	NM_007372; NM_203499
	NM_028074
	NP_031398; NP_987095
	NP_082350; NP_001348569; NP_001348571; NP_001348572; NP_001348573
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene.^[5]^[6]

Function

This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.^[6]

DDX42 has been shown to interact with SF3B1.^[7]

1 2 3 GRCh38: Ensembl release 89: ENSG00000198231 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020705 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Suk K, Kim S, Kim YH, Oh SH, Lee MK, Kim KW, Kim HD, Seo YS (Apr 2000). "Identification of a novel human member of the DEAD box protein family". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1501 (1): 63–9. doi:10.1016/S0925-4439(00)00010-7. PMID 10727850.
1 2 "Entrez Gene: DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42".
↑ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.