(S)-methylmalonyl-CoA hydrolase
| (S)-methylmalonyl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.2.17 | ||||||||
| CAS no. | 87928-03-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme (S)-methylmalonyl-CoA hydrolase (EC 3.1.2.17) catalyzes the reaction
The enzyme characterised from liver hydrolyses (S)-methylmalonyl-CoA to coenzyme A and methylmalonic acid, which forms the thioester in the starting material.[1][2][3] The starting material is produced from propionyl-CoA, a breakdown product of some amino acids, and an increase of methylmalonic acid is a marker of vitamin B12 deficiency as methylmalonyl-CoA is converted to succinyl-CoA by an enzyme using the vitamin as a cofactor.[4]
This enzyme is a hydrolase, specifically one acting on thioester bonds. The systematic name of this enzyme class is (S)-methylmalonyl-CoA hydrolase. This enzyme is also called D-methylmalonyl-coenzyme A hydrolase.[5]
References
- ↑ Kovachy, R. J.; Copley, S. D.; Allen, R. H. (1983). "Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme a hydrolase". Journal of Biological Chemistry. 258 (18): 11415–11421. doi:10.1016/S0021-9258(17)44433-4. PMID 6885824.
- ↑ Kovachy, Robin J.; Stabler, Sally P.; Allen, Robert H. (1988). "D-methylmalonyl-CoA hydrolase". Branched-Chain Amino Acids. Methods in Enzymology. Vol. 166. pp. 393–400. doi:10.1016/S0076-6879(88)66051-4. ISBN 978-0-12-182067-1. PMID 3071714.
- ↑ Schomburg, Dietmar; Stephan, Dörte (1998). "(S)-Methylmalonyl-CoA hydrolase". Enzyme Handbook 15. pp. 79–81. doi:10.1007/978-3-642-58948-5_19. ISBN 978-3-540-64116-2.
- ↑ Dhar, Indu; Lysne, Vegard; Ulvik, Arve; et al. (2023). "Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study". Journal of Internal Medicine. 293 (4): 508–519. doi:10.1111/joim.13610. hdl:11250/3117991. PMID 36682040.
- ↑ Enzyme 3.1.2.17 at KEGG Pathway Database.
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