D-alanine 2-hydroxymethyltransferase
| D-alanine 2-hydroxymethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.2.7 | ||||||||
| CAS no. | 9075-76-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) is an enzyme that catalyzes the chemical reaction
-2-Methylserine.svg.png)
This tetrahydrofolate–dependent enzyme catalyzes a reversible substitution of the formyl group from the cofactor 10-methylenetetrahydrofolate (5,10-CH2-THF) to D-alanine to give 2-methyl-L-serine and tetrahydrofolic acid (THF).[1]
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase. This enzyme is also called 2-methylserine hydroxymethyltransferase. This enzyme participates in the one carbon pool by folate.[2]
References
- ↑ Wilson EM, Snell EE (October 1962). "Metabolism of alpha-methylserine. I. alpha-Methylserine hydroxymethyltransferase". The Journal of Biological Chemistry. 237 (10): 3171–9. doi:10.1016/S0021-9258(18)50139-3. PMID 14001018.
- ↑ Enzyme 2.1.2.7 at KEGG Pathway Database.
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