Columbamine O-methyltransferase
| Columbamine O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.118 | ||||||||
| CAS no. | 105843-76-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Columbamine O-methyltransferase (EC 2.1.1.118) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the benzylisoquinoline alkaloid, columbamine, is converted to palmatine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Berberis wilsoniae.[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:columbamine O-methyltransferase. It is part of the alkaloid biosynthesis pathway.[2]
References
- ↑ Rueffer M, Amann M, Zenk MH (1986). "S-Adenosyl-L-methionine:columbamine O-methyltransferase, a compartmentalized enzyme in protoberberine biosynthesis". Plant Cell Reports. 5 (3): 182–185. Bibcode:1986PCelR...5..182R. doi:10.1007/BF00269113. PMID 24248127.
- ↑ Enzyme 2.1.1.118 at KEGG Pathway Database.
Categories: