Clearfil SE Bond

Clearfil SE Bond is a dental adhesive introduced in 1999 by the Japanese manufacturer Kuraray Medical (since 2012 part of Kuraray Noritake Dental Inc.). It is a two-step, light-cured self-etch system: a primer and a separate bonding resin are applied to the prepared tooth without a prior phosphoric acid etch-and-rinse step.[1][2][3] Both components contain the 10-MDP functional monomer, which Kuraray developed in 1981.[4][5]

Background

Dental adhesives are grouped into "generations" by the number of clinical steps and the etching strategy used. CLEARFIL SE Bond is a sixth-generation, two-step self-etch system: a self-etching primer is applied first, followed by a bonding resin, with no separate phosphoric acid etch or rinse.[6][3]

10-MDP was synthesised at Kuraray in Kurashiki, Japan, in 1981.[4][5] Kuraray had earlier used a self-etching primer in CLEARFIL Liner Bond 2 (1993); CLEARFIL SE Bond, released in 1999, applied the same approach in a two-bottle form.[1][3]

Composition

The adhesive is supplied as two liquids. The primer contains 10-MDP, HEMA, a hydrophilic dimethacrylate and water, and has a pH of about 1.9–2.[7][1][3] The bonding resin contains 10-MDP, Bis-GMA, HEMA and a hydrophobic dimethacrylate. Both are cured with a dental curing light.

When applied, the acidic primer demineralises and infiltrates the smear layer and the superficial dentin in a single step, producing a thin hybrid layer (about 0.5–1 μm thick) in which residual hydroxyapatite crystals remain attached to the collagen fibrils.[1][3] 10-MDP forms ionic bonds with the residual hydroxyapatite, producing MDP–calcium salts that self-assemble into a nano-layered structure at the resin–dentin interface.[4][5] Because the primer is milder than phosphoric acid etchants, the etch pattern produced in uncut enamel is shallower than with an etch-and-rinse technique.[3]

Clinical performance

Most published clinical data on CLEARFIL SE Bond come from restorations placed in non-carious cervical lesions (Class V), with retention as the primary outcome.[8][9]

A research group at KU Leuven followed one cohort over more than a decade, reporting 97% retention at eight years[1] and continued good clinical performance at thirteen years; selective enamel etching had only a minor positive effect on marginal integrity and marginal discoloration, and did not significantly affect retention.[10] A 2010 two-year trial in restorations placed by general dentists without specialised adhesive-research experience reported 81–84% retention.[7] A two-year trial by Türkün comparing CLEARFIL SE Bond with the etch-and-rinse adhesive Prime&Bond NT found retention rates of 93% and 91%, with no statistically significant difference.[11]

A 2015 meta-analysis of 81 prospective cervical-lesion trials covering 47 adhesives found that two-step self-etch and three-step etch-and-rinse adhesives outperformed one-step self-etch systems and glass-ionomer-based materials on a composite clinical index.[8] A 2021 network meta-analysis of randomised trials in cervical lesions ranked two-step self-etch and three-step etch-and-rinse adhesives among the best-performing strategies.[12] A 2022 systematic review and meta-analysis in Operative Dentistry pooled 14 randomised trials comparing CLEARFIL SE Bond with other adhesives in non-carious cervical lesions and found no statistically significant differences in retention at 12–24 or 36–48 months.[13]

CLEARFIL SE Bond 2

A successor, CLEARFIL SE Bond 2, uses a 10-MDP-based primer and bonding resin with a modified catalyst system. When combined with a separately sold dual-cure activator, the bonding agent can be cured in dual-cure mode; the manufacturer indicates this mode for indirect restorations and core build-ups.[14]

References

  1. 1 2 3 4 5 Peumans, M.; De Munck, J.; Van Landuyt, K.L.; Poitevin, A.; Lambrechts, P.; Van Meerbeek, B. (2010). "Eight-year clinical evaluation of a 2-step self-etch adhesive with and without selective enamel etching". Dental Materials. 26 (12): 1176–1184. doi:10.1016/j.dental.2010.08.190. PMID 20947155.
  2. ↑ "What is the difference between Clearfil Photo Bond and Clearfil SE Bond?". Kuraray Noritake Dental. Retrieved 2026-05-11.
  3. 1 2 3 4 5 6 Van Meerbeek, B.; Yoshihara, K.; Yoshida, Y.; Mine, A.; De Munck, J.; Van Landuyt, K.L. (2011). "State of the art of self-etch adhesives". Dental Materials. 27 (1): 17–28. doi:10.1016/j.dental.2010.10.023. PMID 21109301.
  4. 1 2 3 Yoshihara, K.; Yoshida, Y.; Hayakawa, S.; Nagaoka, N.; Irie, M.; Ogawa, T.; Van Landuyt, K.L.; Osaka, A.; Suzuki, K.; Minagi, S.; Van Meerbeek, B. (2011). "Nanolayering of phosphoric acid ester monomer on enamel and dentin". Acta Biomaterialia. 7 (8): 3187–3195. doi:10.1016/j.actbio.2011.04.026. PMID 21536154.
  5. 1 2 3 Yoshida, Y.; Nagakane, K.; Fukuda, R.; Nakayama, Y.; Okazaki, M.; Shintani, H.; Inoue, S.; Tagawa, Y.; Suzuki, K.; De Munck, J.; Van Meerbeek, B. (2004). "Comparative study on adhesive performance of functional monomers". Journal of Dental Research. 83 (6): 454–458. doi:10.1177/154405910408300604. PMID 15153451.
  6. ↑ Sofan, E.; Sofan, A.; Palaia, G.; Tenore, G.; Romeo, U.; Migliau, G. (2017). "Classification review of dental adhesive systems: from the IV generation to the universal type". Annali di Stomatologia. 8 (1): 1–17. PMC 5507161. PMID 28736601.
  7. 1 2 Brackett, M.G.; Dib, A.; Franco, G.; Estrada, B.E.; Brackett, W.W. (2010). "Two-year clinical performance of Clearfil SE and Clearfil S3 in restoration of unabraded non-carious class V lesions". Operative Dentistry. 35 (3): 273–278. doi:10.2341/09-266-C. PMID 20533626.
  8. 1 2 Mahn, E.; Rousson, V.; Heintze, S. (2015). "Meta-Analysis of the Influence of Bonding Parameters on the Clinical Outcome of Tooth-colored Cervical Restorations". The Journal of Adhesive Dentistry. 17 (5): 391–403. doi:10.3290/j.jad.a35008. PMID 26525003.
  9. ↑ Peumans, M.; De Munck, J.; Mine, A.; Van Meerbeek, B. (2014). "Clinical effectiveness of contemporary adhesives for the restoration of non-carious cervical lesions. A systematic review". Dental Materials. 30 (10): 1089–1103. doi:10.1016/j.dental.2014.07.007. PMID 25091214.
  10. ↑ Peumans, M.; De Munck, J.; Van Landuyt, K.; Van Meerbeek, B. (2015). "Thirteen-year randomized controlled clinical trial of a two-step self-etch adhesive in non-carious cervical lesions". Dental Materials. 31 (3): 308–314. doi:10.1016/j.dental.2015.01.005. PMID 25637318.
  11. ↑ Türkün, L.S. (2003). "Clinical evaluation of a self-etching and a one-bottle adhesive system at two years". Journal of Dentistry. 31 (8): 527–534. doi:10.1016/S0300-5712(03)00102-2. PMID 14554069.
  12. ↑ Dreweck, F.D.S.; Burey, A.; Oliveira Dreweck, M.de; Loguercio, A.D.; Reis, A. (2021). "Adhesive strategies in cervical lesions: systematic review and a network meta-analysis of randomized controlled trials". Clinical Oral Investigations. 25 (5): 2495–2510. doi:10.1007/s00784-021-03844-5. PMID 33661448.
  13. ↑ Dreweck, F.D.S.; Burey, A.; Oliveira Dreweck, M.de; Fernandez, E.; Loguercio, A.D.; Reis, A. (2021). "Challenging the Concept that OptiBond FL and Clearfil SE Bond in NCCLs Are Gold Standard Adhesives: A Systematic Review and Meta-analysis". Operative Dentistry. 46 (6): E276–E295. doi:10.2341/20-059-LIT. PMID 34919728.
  14. ↑ "CLEARFIL SE Bond 2". Kuraray Noritake Dental. Retrieved 2026-05-11.
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