Citramalyl-CoA lyase, mitochondrial is an enzyme that in humans is encoded by the CLYBL gene.[5] One of its main functions involves participating in the detoxification of poisonous vitamin B12 metabolites in the mitochondria.[6] As part of that it converts citramalyl-CoA into acetyl-CoA and pyruvate (acting as a Citramalyl-CoA lyase), and can also detoxify malyl-CoA (acting as a malyl-CoA thioesterase).[6] It has also been shown to be able to act as a malate synthase, but only in vitro in the lab.[6]
Further reading
- Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (December 2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutat. Res. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.
- Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (September 2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9) e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
