Cyclin dependent kinase like 1

CDKL1
Identifiers
Aliases	CDKL1, KKIALRE, P42, cyclin dependent kinase like 1
External IDs	OMIM: 603441; MGI: 1918341; GeneCards: CDKL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AGU
Enzyme activity
Gene location (Human)
Chr.	Chromosome 14 (human)
End	50,416,461 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	69,838,041 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; Achilles tendon; ; canal of the cervix; ; body of uterus; ; ectocervix; ; epithelium of colon; ; muscle layer of sigmoid colon; ; right lobe of thyroid gland; ; left ovary; ; monocyte;
	Top expressed in
	right kidney; ; human kidney; ; lumbar subsegment of spinal cord; ; spermatid; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; blood; ; visual cortex; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; ATP binding; kinase activity; cyclin-dependent protein serine/threonine kinase activity;
Cellular component	cytoplasm; extracellular exosome; nucleus; nucleoplasm; intracellular membrane-bounded organelle; ciliary transition zone;
Biological process	development of the heart; phosphorylation; regulation of cell cycle; protein phosphorylation; regulation of cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8814
	71091
	ENSG00000100490
	ENSMUSG00000020990
	Q00532
	Q8CEQ0
	NM_001282236; NM_004196; NM_001367064; NM_001367065
	NM_183294
	NP_001269165; NP_004187; NP_001353993; NP_001353994
	NP_899117
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene.^[5]

Function

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus, and two transcript variants encoding different isoforms have been found for this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100490 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020990 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Cyclin dependent kinase like 1". Retrieved 2016-06-07.

Function

References

Further reading