CDC26

CDC26
Identifiers
Aliases	CDC26, ANAPC12, APC12, C9orf17, cell division cycle 26
External IDs	OMIM: 614533; MGI: 1913690; GeneCards: CDC26
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HYM, 4UI9, 5A31, 5G05, 5G04,%%s4UI9, 5A31
Gene location (Human)
Chr.	Chromosome 9 (human)
End	113,275,572 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	62,326,879 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; mucosa of transverse colon; ; monocyte; ; islet of Langerhans; ; granulocyte; ; apex of heart; ; lymph node; ; left ventricle; ; rectum; ; right lung;
	Top expressed in
	ventricular zone; ; medial ganglionic eminence; ; yolk sac; ; abdominal wall; ; embryo; ; endocardial cushion; ; maxillary prominence; ; mandibular prominence; ; embryo; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; anaphase-promoting complex; nucleus; nucleoplasm;
Biological process	regulation of mitotic metaphase/anaphase transition; cell cycle; anaphase-promoting complex-dependent catabolic process; protein ubiquitination; protein K11-linked ubiquitination; cell division; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process; regulation of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	246184
	66440
	ENSG00000176386
	ENSMUSG00000066149
	Q8NHZ8
	Q99JP4
	NM_139286
	NM_139291; NM_001368241
	NP_644815; NP_644815.1
	NP_647452; NP_001355170
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division cycle 26 is a protein that in humans is encoded by the CDC26 gene.^[5]

Function

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008].

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Anaphase-promoting complex subunit CDC26

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000176386 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066149 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Cell division cycle 26". Retrieved 2018-10-16.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000176386 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066149 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Cell division cycle 26". Retrieved 2018-10-16.

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