Cyclin E2

CCNE2
Identifiers
Aliases	CCNE2, CYCE2, cyclin E2
External IDs	OMIM: 603775; MGI: 1329034; GeneCards: CCNE2
Gene location (Human) Chr. Chromosome 8 (human) Band 8q22.1 Start 94,879,770 bp End 94,896,678 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A1 Start 11,191,351 bp End 11,204,779 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum C1 segment inferior ganglion of vagus nerve bone marrow ganglionic eminence testicle ventricular zone gonad bone marrow cell subthalamic nucleus Top expressed in spermatocyte primitive streak human fetus tail of embryo genital tubercle abdominal wall yolk sac medial ganglionic eminence fetal liver hematopoietic progenitor cell dermis More reference expression data BioGPS n/a
Gene ontology Molecular function cyclin-dependent protein serine/threonine kinase regulator activity protein binding cyclin-dependent protein serine/threonine kinase activity protein kinase binding protein kinase activity Cellular component cytosol nucleus nucleoplasm cyclin E2-CDK2 complex cyclin-dependent protein kinase holoenzyme complex cytoplasm centrosome Biological process cell division cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity DNA replication initiation regulation of cell cycle telomere maintenance homologous chromosome pairing at meiosis chromosome organization involved in meiotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle protein phosphorylation regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 9134 12448 Ensembl ENSG00000175305 ENSMUSG00000028212 UniProt O96020 Q9Z238 RefSeq (mRNA) NM_004702 NM_057735 NM_057749 NM_001037134 NM_001282943 NM_009830 RefSeq (protein) NP_477097 NP_001032211 NP_001269872 NP_033960 Location (UCSC) Chr 8: 94.88 – 94.9 Mb Chr 4: 11.19 – 11.2 Mb PubMed search
Wikidata
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Cyclin E2
Identifiers
Symbol	CCNE2
NCBI gene	9134
HGNC	1590
OMIM	603775
RefSeq	NM_057749
UniProt	O96020
Other data
Locus	Chr. 8 q22.1
Search for Structures Swiss-model Domains InterPro

Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1). It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.

Further reading

• Zariwala M, Liu J, Xiong Y (November 1998). "Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins". Oncogene. 17 (21): 2787–2798. doi:10.1038/sj.onc.1202505. PMID 9840943. S2CID 7340570.