CATSPERQ

CATSPERQ
Identifiers
Aliases	CATSPERQ, C8ORFK29, TMEM 249, transmembrane protein 249, TMEM249, catsper channel auxiliary subunit theta
External IDs	MGI: 3647471; GeneCards: CATSPERQ
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.3 Start 144,352,219 bp End 144,354,954 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 D3 Start 76,417,413 bp End 76,419,566 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis testicle right hemisphere of cerebellum mucosa of transverse colon primary visual cortex granulocyte right frontal lobe ganglionic eminence Brodmann area 9 Top expressed in spermatid testicle spermatocyte morula embryo secondary oocyte embryo primary oocyte zygote olfactory bulb More reference expression data BioGPS n/a
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 340393 666504 Ensembl ENSG00000261587 ENSG00000285272 ENSMUSG00000116376 UniProt Q2WGJ8 n/a RefSeq (mRNA) NM_001252402 NM_001252404 NM_001280561 NM_001378247 RefSeq (protein) NP_001239331 NP_001239333 NP_001267490 n/a Location (UCSC) Chr 8: 144.35 – 144.35 Mb Chr 15: 76.42 – 76.42 Mb PubMed search
Wikidata
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Cation channel sperm-associated auxiliary subunit theta is a protein that in humans is encoded by the CATSPERQ gene (previously TMEM249). The CATSPERQ protein is part of the CatSper complex which is involved in the movement of sperm (in particular hyperactivation).

Locus

CATSPERQ is located near the end of the long arm of chromosome 8 in humans.

General position of CATSPERQ on human chromosome 8 marked by a red line.

Common aliases

CATSPERQ is also known as TMEM249 or C8orfk29.

Primary sequence and variants or isoforms

Isoforms and splice variants of CATSPERQ provided by NCBI's Aceview and Softberry

The primary sequence found at NCBI and Aceview on NCBI predicts there are five spliceforms, with four closely resembling one another and the fifth missing a large 5' intron region. Softberry reinforces the Aceview data by predicting five exons, which are seen in four of the five spliceforms of Aceview.

The general structure of the CATSPERQ transcript has a large 5' UTR followed by exon 1, then a large intron followed by exon 2, a small intron then exon 3. The rest of the protein follows exon 3 with a large intron, exon 4 a small intron then exon 5, the 3' UTR.

The primary transcript contains all five exons and produces a protein that is 235 amino acids long. Transcript 1 and 2 are translated in the 3' to 5' direction while transcripts 3 through 5 are translated in the 5' to 3' direction. The gene is encoded on the minus strand within the chromosome.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.