Beta-diketone hydrolase
| beta-diketone hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.7.1.7 | ||||||||
| CAS no. | 97955-12-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a beta-diketone hydrolase (EC 3.7.1.7) is an enzyme that catalyzes the chemical reaction
- nonane-4,6-dione + H2O pentan-2-one + butanoate
Thus, the two substrates of this enzyme are nonane-4,6-dione and H2O, whereas its two products are 2-pentanone and butanoate.
This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is nonane-4,6-dione acylhydrolase. This enzyme is also called oxidized PVA hydrolase.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 2J5G and PDB: 2J5S.
References
- Sakai K, Hamada N, Watanabe Y (1983). "Separation of secondary alcohol oxidase and oxidized poly(vinyl alcohol) hydrolase by hydrophobic and dye-ligand chromatographies". Agric. Biol. Chem. 47: 153–155. doi:10.1271/bbb1961.47.153.
- Sakai K, Hamada N, Watanabe Y (1985). "A new enzyme, beta-diketone hydrolase: a component of a poly(vinyl alcohol)-degrading enzyme preparation". Agric. Biol. Chem. 49 (6): 1901–1902. doi:10.1271/bbb1961.49.1901.