BZIP intron animal

Consensus secondary structure and sequence conservation of bZIP intron in animals

The bZIP intron animal is an unconventional bZIP intron in animals located in the mRNA of Xbp1 orthologs.[1] The RNA structure consists of two hairpins of similar length with loop regions defining the splice sites. Intron is usually 23 or 26 nt long and it is excised by endoribonuclease Ire1 encoded by ERN1 gene in response to ER stress. Splicing of this intron causes a frameshift in Xbp1 mRNA that introduces a new C-terminal transactivation domain, producing the active spliced transcription factor.[2][3] The splicing mechanism in this group was first reported in human.[3]

References

  1. ↑ Hooks KB, Griffiths-Jones S (2011). "Conserved RNA structures in the non-canonical Hac1/Xbp1 intron". RNA Biol. 8 (4): 552–556. doi:10.4161/rna.8.4.15396. PMC 3225973. PMID 21593604.
  2. ↑ Coelho DS, Domingos PM (2014). "Ire1 Mediated mRNA Splicing in a C-Terminus Deletion Mutant of Drosophila Xbp1". PLOS ONE. 9 (8) e105588. Bibcode:2014PLoSO...9j5588C. doi:10.1371/journal.pone.0105588. PMC 4135531. PMID 25133546.
  3. 1 2 Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001). "XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor". Cell. 107 (7): 881–891. doi:10.1016/S0092-8674(01)00611-0. PMID 11779464.
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