BRAP

BRAP
Identifiers
Aliases	BRAP, BRAP2, IMP, RNF52, BRCA1 associated protein
External IDs	OMIM: 604986; MGI: 1919649; GeneCards: BRAP
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.12 Start 111,642,146 bp End 111,685,956 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 121,798,626 bp End 121,825,319 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis secondary oocyte sperm buccal mucosa cell gonad Achilles tendon gastrocnemius muscle islet of Langerhans testicle Top expressed in spermatid spermatocyte seminiferous tubule right kidney zygote lumbar spinal ganglion secondary oocyte lip dentate gyrus of hippocampal formation granule cell left lobe of liver More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin protein ligase activity zinc ion binding metal ion binding ubiquitin-protein transferase activity protein binding nuclear localization sequence binding identical protein binding nucleic acid binding transferase activity Cellular component cytoplasm nuclear membrane ubiquitin ligase complex cytosol Biological process MAPK cascade protein ubiquitination negative regulation of signal transduction Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 8315 72399 Ensembl ENSG00000089234 ENSMUSG00000029458 UniProt Q7Z569 Q99MP8 RefSeq (mRNA) NM_006768 NM_001289543 NM_001289544 NM_028227 RefSeq (protein) NP_006759 NP_001276472 NP_001276473 NP_082503 Location (UCSC) Chr 12: 111.64 – 111.69 Mb Chr 5: 121.8 – 121.83 Mb PubMed search
Wikidata
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BRCA1 associated protein is a protein that in humans is encoded by the BRAP gene.

Function

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008].

Further reading

• Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA (January 2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature. 427 (6971): 256–60. Bibcode:2004Natur.427..256M. doi:10.1038/nature02237. PMID 14724641. S2CID 4416552.
• Asada M, Ohmi K, Delia D, Enosawa S, Suzuki S, Yuo A, Suzuki H, Mizutani S (September 2004). "Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation". Mol. Cell. Biol. 24 (18): 8236–43. doi:10.1128/MCB.24.18.8236-8243.2004. PMC 515069. PMID 15340083.
• Chen C, Lewis RE, White MA (May 2008). "IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds". J. Biol. Chem. 283 (19): 12789–96. doi:10.1074/jbc.M709305200. PMC 2442335. PMID 18332145.
• Mallin EA, Pavlicek W (April 2008). "55-year-old woman with menopausal symptoms and a family history of breast cancer". Mayo Clin. Proc. 83 (4): 485–8. doi:10.4065/83.4.485. PMID 18380995.
• Czyzyk J, Chen HC, Bottomly K, Flavell RA (August 2008). "p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells". J. Biol. Chem. 283 (34): 23004–15. doi:10.1074/jbc.M804084200. PMC 2516986. PMID 18577512.
• Keinan-Boker L, Lerner-Geva L, Kaufman B, Meirow D (October 2008). "Pregnancy-associated breast cancer". Isr. Med. Assoc. J. 10 (10): 722–7. PMID 19009954.
• Chen JS, Hu HY, Zhang S, He M, Hu RM (May 2009). "Brap2 facilitates HsCdc14A Lys-63 linked ubiquitin modification". Biotechnol. Lett. 31 (5): 615–21. doi:10.1007/s10529-009-9914-7. PMID 19152073. S2CID 22550914.
• Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T (March 2009). "SNPs in BRAP associated with risk of myocardial infarction in Asian populations". Nat. Genet. 41 (3): 329–33. doi:10.1038/ng.326. PMID 19198608. S2CID 27136281.
• Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T (March 2009). "SNPs in BRAP associated with risk of myocardial infarction in Asian populations". Nat. Genet. 41 (3): 329–33. doi:10.1038/ng.326. PMID 19198608. S2CID 27136281.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.