Beta-pyrazolylalanine synthase
| Beta-pyrazolylalanine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.51 | ||||||||
| CAS no. | 37290-81-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Beta-pyrazolylalanine synthase (EC 2.5.1.51) is an enzyme that catalyzes the chemical reaction
It was first characterised from Leucaena leucocephala and transfers the 2-amino-2-carboxyethyl group from its substrate, the amino acid O-acetylserine, to pyrazole, giving β-pyrazolyl-L-alanine. Acetic acid (CH3CO2H) is a byproduct.[1][2] The enzyme is also found in Citrullus vulgaris (watermelon) and, unlike some other cysteine synthase enzymes which use O-acetylserine, in this species is specific for pyrazole.[3][4]
This enzyme is a transferase, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase. Other names in common use include beta-(1-pyrazolyl)alanine synthase, beta-pyrazolealanine synthase, beta-pyrazolylalanine synthase (acetylserine), O3-acetyl-L-serine acetate-lyase (adding pyrazole), BPA-synthase, pyrazolealanine synthase, pyrazolylalaninase, and 3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase.[5]
References
- ↑ Murakoshi I, Kuramoto H, Haginiwa J (1972). "The enzymic synthesis of beta-substituted alanines". Phytochemistry. 11 (1): 177–182. Bibcode:1972PChem..11..177M. doi:10.1016/S0031-9422(00)89986-0.
- ↑ Murakoshi I, Ikegami F, Hinuma Y, Hanma Y (1984). "Purification and characterization of L-mimosine synthase from Leucaena leucocephala". Phytochemistry. 23 (9): 1905–1908. Bibcode:1984PChem..23.1905M. doi:10.1016/S0031-9422(00)84938-9.
- ↑ Murakoshi I, Ikegami F, Hinuma Y, Hanma Y (1984). "Purification and characterization of beta-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris". Phytochemistry. 23 (5): 973–977. Bibcode:1984PChem..23..973M. doi:10.1016/S0031-9422(00)82594-7.
- ↑ Noji M, Murakoshi I, Saito K (1993). "Evidence for identity of beta-pyrazolealanine synthase with cysteine synthase in watermelon: formation of beta-pyrazole-alanine by cloned cysteine synthase in vitro and in vivo". Biochem. Biophys. Res. Commun. 197 (3): 1111–7. Bibcode:1993BBRC..197.1111N. doi:10.1006/bbrc.1993.2592. PMID 8280125.
- ↑ Enzyme 2.5.1.51 at KEGG Pathway Database.