Andrew Paul Feinberg

Andrew Paul Feinberg
Born(1952-08-05)August 5, 1952
Alma mater
Known forcancer epigenetics
Scientific career
Workplaces

Andrew Paul Feinberg (born August 5, 1952) is the director of the Center for Epigenetics, chief of the Division of Molecular Medicine in the Department of Medicine, and the King Fahd Professor of Medicine, Oncology, and Molecular Biology & Genetics in the School of Medicine at Johns Hopkins University.[1] He is the Bloomberg Distinguished Professor of Epigenetics.[2] He holds appointments in the Departments of Medicine, Oncology, Molecular Biology & Genetics, and Psychiatry & Behavioral Sciences in the School of Medicine; in the Departments of Mental Health and Biostatistics in the Bloomberg School of Public Health; and in the Department of Biomedical Engineering in the Whiting School of Engineering.[3]

Feinberg is known for research on the role of epigenetic alterations in cancer, including the identification of widespread DNA methylation abnormalities and the role of genomic imprinting in tumor development. Feinberg’s research demonstrated that large-scale epigenomic alterations—including global DNA hypomethylation and partially methylated domains—contribute to tumor initiation, progression, and cellular heterogeneity. This work contributed to the development of the concept of epigenetic plasticity as a driver of cancer evolution. Feinberg's research has contributed to understanding the role of the epigenome as a central driver of cancer biology, identified causal epigenetic mechanisms for cancer risk and progression, and foundations for new approaches to cancer detection, prevention, and therapeutic intervention.[4] He has also studied the epigenetics of common disease generally, with applications to metabolic, immunologic, and neuropsychiatric disease, and the integration of genetic risk with environmental exposure through the epigenome.[5][6]

Early life and education

Feinberg completed the Yale University Directed Studies intensive program from 1969 to 1972, and received his B.A. in 1973 and M.D. in 1976 from the accelerated medical program at Johns Hopkins University, as well as an M.P.H. from Johns Hopkins in 1981. He completed his residency in internal medicine, followed by a fellowship in genetics at Hopkins. He completed a postdoctoral fellowship in developmental biology at University of California, San Diego, where he researched the multiple differentiation paths of Dictyostelium discoideum.[7] His research into cancer epigenetics and inheritance of traits other than by DNA was initially seen as controversial, and he was told that if he continued this work, his funding would be cut off.[8]

Career

Feinberg discovered epigenetic alterations in human cancer with Bert Vogelstein in 1983 at Johns Hopkins University.[9] This work stemmed from Feinberg's hypothesis that epigenetic changes could underlie plasticity in cancer processes such as invasion and metastasis, drawing on his earlier research on developmental plasticity in Dictyostelium discoideum.[10] This discovery provided evidence that loss of DNA methylation (hypomethylation) is a consistent feature of human tumors, contributing to the development of the field of cancer epigenetics.[11] He is also credited with the discovery of some genes subject to gene imprinting in humans, the role of loss of gene imprinting in cancer, and the role of epigenetic variants in common disease generally.[1][9]

From 1986 to 1994, Feinberg served as a Howard Hughes Medical Institute (HHMI) Investigator at the University of Michigan, where he continued his work in epigenetics. During this period, he discovered the molecular basis of Beckwith-Wiedemann Syndrome (BWS), reporting that this overgrowth disorder results from disruption of imprinted genes on chromosome 11p15.[12][13][14][15][16] This work provided evidence for a role of epigenetics in cancer and helped establish the role of epigenetic mechanisms in human disease beyond cancer.[17][18]

In 1994, Feinberg returned to Johns Hopkins University as King Fahd Professor of Molecular Medicine in the Department of Medicine. He subsequently founded and became director of the Center for Epigenetics at Johns Hopkins, the first dedicated NIH-funded Epigenome Center for epigenetics in the United States.[8] In 2015, he was named a Bloomberg Distinguished Professor at Johns Hopkins University.[3]

Research

Feinberg has made contributions to understanding how epigenetic changes drive cancer development and progression. His early work found that cancer cells routinely exhibit hypomethylation, a decrease in the number of methyl groups added to DNA.[9] Feinberg also discovered that epigenetic disruptions occur in immature cells called progenitor cells early in cancer development, often before the genetic mutations traditionally associated with cancer appear. This finding suggested that many different types of cancer may share a common underlying basis rooted in epigenetic changes.[19]

Feinberg's research has examined how genomic imprinting contributes to human disease. His laboratory discovered that the gene IGF2, which promotes cell growth, is normally active only when inherited from the father. In some individuals, however, this gene becomes abnormally active on both parental copies, a phenomenon called "loss of imprinting."[13][12] Feinberg reported that this epigenetic change is responsible for increased cancer risk in children with Beckwith-Wiedemann syndrome,[20] a childhood overgrowth disorder,[13] and that the disorder is also associated with in vitro fertilization.[21] This work provided evidence that epigenetic changes are not only a consequence of cancer but can cause it by expanding the population of cells that are vulnerable to becoming cancerous.[22][23] This work also led to the first epigenetic test for cancer predisposition.[24]

His findings suggest that loss of imprinting may also contribute to common adult cancers,[25][26] indicating that epigenetic alterations may be an important mechanism in cancer development.[27][28] He has also conducted studies of the role of epigenetic entropy, developing mathematical methods to identify the genes responsible for cancer plasticity in acute lymphoblastic leukemia and other cancers.[29][30]

Feinberg's work has contributed to the development of the field of epigenomics, which studies epigenetic changes across the entire genome rather than individual genes. He has proposed that epigenetics contributes generally to disease by disrupting phenotypic plasticity.[31] He founded the first epigenome center in the United States supported by the National Institutes of Health.[32] His laboratory has made several discoveries, including the identification of DNA regions called CpG island shores that drive gene expression differences that distinguish different tissues in the body from each other and from cancer.[33][34] Feinberg's recent cancer research has focused on pancreatic ductal adenocarcinoma (PDAC), reporting that metastases arise through epigenetic change in the absence of additional new driver mutations.[35] He has reported a cascade of epigenetic modulators, modifiers, and mediators that drive metastasis that may represent new therapeutic targets for cancer treatment.[36][37] Feinberg discovered the role of partially methylated domains in driving epigenetic instability, leading to hypermethylated CpG islands, and hypomethylated CpG island shores.[38][39]

Feinberg's team created the first comprehensive map of epigenetic marks during normal blood cell development,[40] which correspond to the sites of differential methylation in stem cell reprogramming.[41] Feinberg's research has also expanded to investigate the role of epigenetic changes in diseases other than cancer, including autoimmune,[42] metabolic,[43][44] and neuropsychiatric diseases.[45][46][47]

He has proposed that stochasticity, as measured by epigenetic entropy, is a driver of evolution in a changing environment.[48] His team has shown that epigenetic entropy plays a role in cancer and aging.[49][29][50][51]

In collaboration with David Threadgill at Texas A&M University, Feinberg discovered that a substantial fraction of epigenetic inheritance occurs through non-Mendelian mechanisms of epigenetic inheritance. He also reported their transmission across multiple generations, including evidence for naturally occurring paramutation in mammals,[52] where the epigenetic pattern of one parental allele is copied onto the other allele and transmitted to the next generation.[53]

Feinberg was a principal investigator on NASA's Twins Study, which examined astronaut Scott Kelly during his year-long mission aboard the International Space Station, comparing his physiological and molecular changes to his identical twin brother Mark Kelly, who remained on Earth. Feinberg's team analyzed epigenetic changes during spaceflight, contributing to understanding the biological effects of long-duration space travel.[54][55]

Awards

Publications

Feinberg has more than 127,000 citations in Google Scholar and an h-index of 130.[59] He is listed by ScholarGPS as #3,408 most cited across all fields, and #2 in epigenetics.[60]

Selected Publications

  • 1983 with B Vogelstein, Hypomethylation distinguishes genes of some human cancers from their normal counterparts, in: Nature. Vol. 301, nº 5895; 89-92.
  • 1993 with S Rainier, LA Johnson, CJ Dobry, AJ Ping, PE Grundy, Relaxation of imprinted genes in human cancer, in: Nature. Vol 362; 747-749.
  • 1994 with MJ Steenman, S Rainier, CJ Dobry, AJ Ping, PE Grundy, Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour, in: Nature Genetics. Vol. 7; 433-439.
  • 2007, Phenotypic plasticity and the epigenetics of human disease, in: Nature. Vol. 447, nº 7143; 433-440.
  • 2009 with R Irizarry, C Ladd-Acosta, B Wen, Z Wu, C Montano, P Onyango, H Cui, K Gabo, M Rongione, M Webster, H Ji, J Potash, S Sabunciyan, Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores, in: Nature Genetics. Vol. 41; 178-186.
  • 2010 with H Ji, LIR Ehrlich, J Seita, P Murakami, A Doi, P Lindau, H Lee, MJ Aryee, K Kim, DJ Rossi, MA Inlay, T Serwold, H Karsunky, L Ho, GQ Daley, IL Weissman, Comprehensive methylome map of lineage commitment from hematopoietic progenitors, in: Nature. Vol. 467; 285-290.
  • 2011 with KD Hansen, W Timp, HC Bravo, S Sabunciyan, B Langmead, OG McDonald, B Wen, H Wu, Y Liu, D Diep, E Briem, K Zhang, RA Irizarry, Increased variation in epigenetic domains across cancer types, in: Nature Genetics. Vol. 43; 768-775.
  • 2013 with Y Liu, JM Aryee, L Padyukov, MD Fallin, E Hesselberg, A Runarsson, L Reinius, N Acevedo, M Taub, M Rönninger, K Shchetynsky, A Scheynius, J Kere, L Alfredsson, L Klareskog, TJ Ekström, Epigenome-wide association data implicates DNA methylation as an intermediary of genetic risk in rheumatoid arthritis, in: Nature Biotechnology. Vol. 31; 142-147.
  • 2017 with OG McDonald, X Li, T Saunders, R Tryggvadottir, SJ Mentch, MO Warmoes, AE Word, A Carrer, TH Salz, S Natsume, KM Stauffer, A Makohon-Moore, Y Zhong, H Wu, KE Wellen, JW Locasale, C Iacobuzio-Donahue, Large-scale epigenomic reprogramming links anabolic glucose metabolism to distant metastasis during the evolution of pancreatic cancer progression, in: Nature Genetics. Vol. 49; 367-376.
  • 2017 with G Jenkinson, E Pujadas, J Goutsias, Potential energy landscapes identify the information-theoretic nature of the epigenome, in: Nature Genetics. Vol. 49; 719-729.

References

  1. 1 2 3 "Andrew Paul Feinberg, M.D., M.P.H., Professor of Medicine". Johns Hopkins Medicine.
  2. ↑ "Andrew Feinberg | Johns Hopkins Bloomberg Distinguished Professorships". Retrieved 2026-07-06.
  3. 1 2 Julie Messersmith / (2015-12-15). "JHU's Charles Bennett and Andrew Feinberg named Bloomberg Distinguished Professors". The Hub. Retrieved 2026-07-06.
  4. ↑ "AACR Announces 2026 Scientific Achievement Award Recipients". American Association for Cancer Research (AACR). Retrieved 2026-07-06.
  5. ↑ Feinberg, Andrew P. (2018-04-05). "The Key Role of Epigenetics in Human Disease Prevention and Mitigation". New England Journal of Medicine. 378 (14): 1323–1334. doi:10.1056/NEJMra1402513. ISSN 0028-4793. PMC 11567374. PMID 29617578.
  6. ↑ "The Epigenetic Landscape". The Pathologist. Retrieved 2026-08-11.
  7. ↑ Feinberg, A P; Springer, W R; Barondes, S H (August 1979). "Segregation of pre-stalk and pre-spore cells of Dictyostelium discoideum: observations consistent with selective cell cohesion". Proceedings of the National Academy of Sciences. 76 (8): 3977–3981. Bibcode:1979PNAS...76.3977F. doi:10.1073/pnas.76.8.3977. PMC 383959. PMID 291057.
  8. 1 2 Feinberg, Andrew (2009). "Interview: Professor Andrew Feinberg speaks to Epigenomics". Epigenomics. 1 (1): 25–7. doi:10.2217/epi.09.8. PMID 22122634.
  9. 1 2 3 Feinberg, Andrew P.; Vogelstein, Bert (January 1983). "Hypomethylation distinguishes genes of some human cancers from their normal counterparts". Nature. 301 (5895): 89–92. Bibcode:1983Natur.301...89F. doi:10.1038/301089a0. ISSN 1476-4687. PMID 6185846.
  10. ↑ Feinberg, Andrew P. (2011), "The Epigenesis of an Epigeneticist", in Schwartz, David A. (ed.), Medicine Science and Dreams: The Making of Physician-Scientists, Dordrecht: Springer Netherlands, pp. 33–44, doi:10.1007/978-90-481-9538-1_3, ISBN 978-90-481-9538-1, retrieved 2026-07-06
  11. ↑ Goelz, Susan E.; Vogelstein, Bert; Hamilton, Stanley R.; Feinberg, Andrew P. (1985-04-12). "Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms". Science. 228 (4696): 187–190. Bibcode:1985Sci...228..187G. doi:10.1126/science.2579435. PMID 2579435.
  12. 1 2 Steenman, M. J.; Rainier, S.; Dobry, C. J.; Grundy, P.; Horon, I. L.; Feinberg, A. P. (July 1994). "Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour". Nature Genetics. 7 (3): 433–439. doi:10.1038/ng0794-433. ISSN 1061-4036. PMID 7920665.
  13. 1 2 3 Rainier, S.; Johnson, L. A.; Dobry, C. J.; Ping, A. J.; Grundy, P. E.; Feinberg, A. P. (1993-04-22). "Relaxation of imprinted genes in human cancer". Nature. 362 (6422): 747–749. Bibcode:1993Natur.362..747R. doi:10.1038/362747a0. hdl:2027.42/62710. ISSN 0028-0836. PMID 8385745.
  14. ↑ Matsuoka, S.; Thompson, J. S.; Edwards, M. C.; Bartletta, J. M.; Grundy, P.; Kalikin, L. M.; Harper, J. W.; Elledge, S. J.; Feinberg, A. P. (1996-04-02). "Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15". Proceedings of the National Academy of Sciences of the United States of America. 93 (7): 3026–3030. doi:10.1073/pnas.93.7.3026. ISSN 0027-8424. PMC 39755. PMID 8610162.
  15. ↑ Lee, Maxwell P.; Hu, Ren-JuHu; Johnson, Laura A.; Feinberg, Andrew P. (February 1997). "Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements". Nature Genetics. 15 (2): 181–185. doi:10.1038/ng0297-181. ISSN 1546-1718. PMID 9020845.
  16. ↑ Ping, A. J.; Reeve, A. E.; Law, D. J.; Young, M. R.; Boehnke, M.; Feinberg, A. P. (May 1989). "Genetic linkage of Beckwith-Wiedemann syndrome to 11p15". American Journal of Human Genetics. 44 (5): 720–723. ISSN 0002-9297. PMC 1715646. PMID 2565083.
  17. ↑ Feinberg, Andrew (2009-10-01). "Interview: Professor Andrew Feinberg Speaks To Epigenomics". Epigenomics. 1 (1): 25–27. doi:10.2217/epi.09.8. ISSN 1750-1911. PMID 22122634.
  18. ↑ Feinberg, Andrew (2014). "DNA methylation in cancer: three decades of discovery". Genome Medicine. 6 (5) 36. doi:10.1186/gm553. ISSN 1756-994X. PMC 4062051. PMID 25031622.
  19. ↑ Feinberg, Andrew P.; Ohlsson, Rolf; Henikoff, Steven (January 2006). "The epigenetic progenitor origin of human cancer". Nature Reviews Genetics. 7 (1): 21–33. doi:10.1038/nrg1748. ISSN 1471-0064. PMID 16369569.
  20. ↑ DeBaun, Michael R.; Niemitz, Emily L.; McNeil, D. Elizabeth; Brandenburg, Sheri A.; Lee, Maxwell P.; Feinberg, Andrew P. (March 2002). "Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects". American Journal of Human Genetics. 70 (3): 604–611. doi:10.1086/338934. ISSN 0002-9297. PMC 384940. PMID 11813134.
  21. ↑ DeBaun, Michael R.; Niemitz, Emily L.; Feinberg, Andrew P. (January 2003). "Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19". American Journal of Human Genetics. 72 (1): 156–160. doi:10.1086/346031. ISSN 0002-9297. PMC 378620. PMID 12439823.
  22. ↑ Kaneda, Atsushi; Wang, Chiaochun J.; Cheong, Raymond; Timp, Winston; Onyango, Patrick; Wen, Bo; Iacobuzio-Donahue, Christine A.; Ohlsson, Rolf; Andraos, Rita; Pearson, Mark A.; Sharov, Alexei A.; Longo, Dan L.; Ko, Minoru S. H.; Levchenko, Andre; Feinberg, Andrew P. (2007-12-26). "Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk". Proceedings of the National Academy of Sciences of the United States of America. 104 (52): 20926–20931. Bibcode:2007PNAS..10420926K. doi:10.1073/pnas.0710359105. ISSN 1091-6490. PMC 2409243. PMID 18087038.
  23. ↑ Ravenel, Jason D.; Broman, Karl W.; Perlman, Elizabeth J.; Niemitz, Emily L.; Jayawardena, Tilanthi M.; Bell, Daphne W.; Haber, Daniel A.; Uejima, Hiroshi; Feinberg, Andrew P. (2001-11-21). "Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor". JNCI: Journal of the National Cancer Institute. 93 (22): 1698–1703. doi:10.1093/jnci/93.22.1698. ISSN 0027-8874. PMID 11717330.
  24. ↑ Lennerz, Jochen K.; Timmerman, Robert J.; Grange, Dorothy K.; DeBaun, Michael R.; Feinberg, Andrew P.; Zehnbauer, Barbara A. (September 2010). "Addition of H19 'loss of methylation testing' for Beckwith-Wiedemann syndrome (BWS) increases the diagnostic yield". The Journal of molecular diagnostics: JMD. 12 (5): 576–588. doi:10.2353/jmoldx.2010.100005. ISSN 1943-7811. PMC 2928421. PMID 20616360.
  25. ↑ Sakatani, Takashi; Kaneda, Atsushi; Iacobuzio-Donahue, Christine A.; Carter, Mark G.; de Boom Witzel, Sten; Okano, Hideyuki; Ko, Minoru S. H.; Ohlsson, Rolf; Longo, Dan L.; Feinberg, Andrew P. (2005-03-25). "Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice". Science. 307 (5717): 1976–1978. Bibcode:2005Sci...307.1976S. doi:10.1126/science.1108080. ISSN 1095-9203. PMID 15731405.
  26. ↑ Cui, H.; Horon, I. L.; Ohlsson, R.; Hamilton, S. R.; Feinberg, A. P. (November 1998). "Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability". Nature Medicine. 4 (11): 1276–1280. doi:10.1038/3260. ISSN 1078-8956. PMID 9809551.
  27. ↑ Cui, Hengmi; Cruz-Correa, Marcia; Giardiello, Francis M.; Hutcheon, David F.; Kafonek, David R.; Brandenburg, Sheri; Wu, Yiqian; He, Xiaobing; Powe, Neil R.; Feinberg, Andrew P. (2003-03-14). "Loss of IGF2 imprinting: a potential marker of colorectal cancer risk". Science. 299 (5613): 1753–1755. Bibcode:2003Sci...299.1753C. doi:10.1126/science.1080902. ISSN 1095-9203. PMID 12637750.
  28. ↑ Hub staff report / (2024-12-09). "Two Johns Hopkins Medicine scientists receive prestigious Harvey Prize". The Hub. Retrieved 2026-07-06.
  29. 1 2 Jenkinson, Garrett; Pujadas, Elisabet; Goutsias, John; Feinberg, Andrew P. (May 2017). "Potential energy landscapes identify the information-theoretic nature of the epigenome". Nature Genetics. 49 (5): 719–729. doi:10.1038/ng.3811. ISSN 1546-1718. PMC 5565269. PMID 28346445.
  30. ↑ Koldobskiy, Michael A.; Jenkinson, Garrett; Abante, Jordi; Rodriguez DiBlasi, Varenka A.; Zhou, Weiqiang; Pujadas, Elisabet; Idrizi, Adrian; Tryggvadottir, Rakel; Callahan, Colin; Bonifant, Challice L.; Rabin, Karen R.; Brown, Patrick A.; Ji, Hongkai; Goutsias, John; Feinberg, Andrew P. (April 2021). "Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis". Nature Biomedical Engineering. 5 (4): 360–376. doi:10.1038/s41551-021-00703-2. ISSN 2157-846X. PMC 8370714. PMID 33859388.
  31. ↑ Feinberg, Andrew P. (2007-05-24). "Phenotypic plasticity and the epigenetics of human disease". Nature. 447 (7143): 433–440. Bibcode:2007Natur.447..433F. doi:10.1038/nature05919. ISSN 1476-4687. PMID 17522677.
  32. ↑ "Centers of Excellence in Genomic Science (CEGS) Awards". www.genome.gov. Retrieved 2026-07-06.
  33. ↑ Bjornsson, Hans T.; Sigurdsson, Martin I.; Fallin, M. Daniele; Irizarry, Rafael A.; Aspelund, Thor; Cui, Hengmi; Yu, Wenqiang; Rongione, Michael A.; Ekström, Tomas J.; Harris, Tamara B.; Launer, Lenore J.; Eiriksdottir, Gudny; Leppert, Mark F.; Sapienza, Carmen; Gudnason, Vilmundur (2008-06-25). "Intra-individual change over time in DNA methylation with familial clustering". JAMA. 299 (24): 2877–2883. Bibcode:2008JAMA..299.2877B. doi:10.1001/jama.299.24.2877. ISSN 1538-3598. PMC 2581898. PMID 18577732.
  34. ↑ Irizarry, Rafael A.; Ladd-Acosta, Christine; Wen, Bo; Wu, Zhijin; Montano, Carolina; Onyango, Patrick; Cui, Hengmi; Gabo, Kevin; Rongione, Michael; Webster, Maree; Ji, Hong; Potash, James; Sabunciyan, Sarven; Feinberg, Andrew P. (February 2009). "The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores". Nature Genetics. 41 (2): 178–186. Bibcode:2009NaGen..41..178I. doi:10.1038/ng.298. ISSN 1546-1718. PMC 2729128. PMID 19151715.
  35. ↑ McDonald, Oliver G.; Li, Xin; Saunders, Tyler; Tryggvadottir, Rakel; Mentch, Samantha J.; Warmoes, Marc O.; Word, Anna E.; Carrer, Alessandro; Salz, Tal H.; Natsume, Sonoko; Stauffer, Kimberly M.; Makohon-Moore, Alvin; Zhong, Yi; Wu, Hao; Wellen, Kathryn E. (March 2017). "Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis". Nature Genetics. 49 (3): 367–376. doi:10.1038/ng.3753. ISSN 1546-1718. PMC 5695682. PMID 28092686.
  36. ↑ Feinberg, Andrew P.; Koldobskiy, Michael A.; Göndör, Anita (May 2016). "Epigenetic modulators, modifiers and mediators in cancer aetiology and progression". Nature Reviews. Genetics. 17 (5): 284–299. doi:10.1038/nrg.2016.13. ISSN 1471-0064. PMC 4888057. PMID 26972587.
  37. ↑ Maeda, Masahiro; Sherman, Kenna; Zhou, Weiqiang; Cheng, Jiaqi; Nihongaki, Yuta; Idrizi, Adrian; Tryggvadottir, Rakel; Camacho, Oscar; Shang, Xingbo; Min, Jimin; Koldobskiy, Michael A.; Maitra, Anirban; Levchenko, Andre; Slusher, Barbara S.; Ji, Hongkai (2026-02-10). "CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1". Molecular Cancer. 25 (1): 75. doi:10.1186/s12943-026-02575-z. ISSN 1476-4598. PMC 12998327. PMID 41668133.
  38. ↑ Wen, Bo; Wu, Hao; Shinkai, Yoichi; Irizarry, Rafael A.; Feinberg, Andrew P. (February 2009). "Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells". Nature Genetics. 41 (2): 246–250. doi:10.1038/ng.297. ISSN 1546-1718. PMC 2632725. PMID 19151716.
  39. ↑ Timp, Winston; Bravo, Hector Corrada; McDonald, Oliver G.; Goggins, Michael; Umbricht, Chris; Zeiger, Martha; Feinberg, Andrew P.; Irizarry, Rafael A. (2014-08-26). "Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors". Genome Medicine. 6 (8): 61. doi:10.1186/s13073-014-0061-y. ISSN 1756-994X. PMC 4154522. PMID 25191524.
  40. ↑ Ji, Hong; Ehrlich, Lauren I. R.; Seita, Jun; Murakami, Peter; Doi, Akiko; Lindau, Paul; Lee, Hwajin; Aryee, Martin J.; Irizarry, Rafael A.; Kim, Kitai; Rossi, Derrick J.; Inlay, Matthew A.; Serwold, Thomas; Karsunky, Holger; Ho, Lena (2010-09-16). "Comprehensive methylome map of lineage commitment from haematopoietic progenitors". Nature. 467 (7313): 338–342. Bibcode:2010Natur.467..338J. doi:10.1038/nature09367. ISSN 1476-4687. PMC 2956609. PMID 20720541.
  41. ↑ Doi, Akiko; Park, In-Hyun; Wen, Bo; Murakami, Peter; Aryee, Martin J.; Irizarry, Rafael; Herb, Brian; Ladd-Acosta, Christine; Rho, Junsung; Loewer, Sabine; Miller, Justine; Schlaeger, Thorsten; Daley, George Q.; Feinberg, Andrew P. (December 2009). "Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts". Nature Genetics. 41 (12): 1350–1353. doi:10.1038/ng.471. ISSN 1546-1718. PMC 2958040. PMID 19881528.
  42. ↑ Liu, Yun; Aryee, Martin J.; Padyukov, Leonid; Fallin, M. Daniele; Hesselberg, Espen; Runarsson, Arni; Reinius, Lovisa; Acevedo, Nathalie; Taub, Margaret; Ronninger, Marcus; Shchetynsky, Klementy; Scheynius, Annika; Kere, Juha; Alfredsson, Lars; Klareskog, Lars (February 2013). "Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis". Nature Biotechnology. 31 (2): 142–147. Bibcode:2013NatBi..31..142L. doi:10.1038/nbt.2487. ISSN 1087-0156. PMC 3598632. PMID 23334450.
  43. ↑ Wulfridge, Phillip; Langmead, Ben; Feinberg, Andrew P.; Hansen, Kasper D. (2019-11-04). "Analyzing whole genome bisulfite sequencing data from highly divergent genotypes". Nucleic Acids Research. 47 (19): e117. doi:10.1093/nar/gkz674. ISSN 1362-4962. PMC 6821270. PMID 31392989.
  44. ↑ Multhaup, Michael L.; Seldin, Marcus M.; Jaffe, Andrew E.; Lei, Xia; Kirchner, Henriette; Mondal, Prosenjit; Li, Yuanyuan; Rodriguez, Varenka; Drong, Alexander; Hussain, Mehboob; Lindgren, Cecilia; McCarthy, Mark; Näslund, Erik; Zierath, Juleen R.; Wong, G. William (2015-01-06). "Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes". Cell Metabolism. 21 (1): 138–149. doi:10.1016/j.cmet.2014.12.014. ISSN 1932-7420. PMC 4340475. PMID 25565211.
  45. ↑ Ladd-Acosta, C.; Hansen, K. D.; Briem, E.; Fallin, M. D.; Kaufmann, W. E.; Feinberg, A. P. (August 2014). "Common DNA methylation alterations in multiple brain regions in autism". Molecular Psychiatry. 19 (8): 862–871. doi:10.1038/mp.2013.114. ISSN 1476-5578. PMC 4184909. PMID 23999529.
  46. ↑ Montano, Carolina; Taub, Margaret A.; Jaffe, Andrew; Briem, Eirikur; Feinberg, Jason I.; Trygvadottir, Rakel; Idrizi, Adrian; Runarsson, Arni; Berndsen, Birna; Gur, Ruben C.; Moore, Tyler M.; Perry, Rodney T.; Fugman, Doug; Sabunciyan, Sarven; Yolken, Robert H. (2016-05-01). "Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study". JAMA Psychiatry. 73 (5): 506–514. doi:10.1001/jamapsychiatry.2016.0144. ISSN 2168-6238. PMC 6353566. PMID 27074206.
  47. ↑ Feinberg, Jason I; Bakulski, Kelly M; Jaffe, Andrew E; Tryggvadottir, Rakel; Brown, Shannon C; Goldman, Lynn R; Croen, Lisa A; Hertz-Picciotto, Irva; Newschaffer, Craig J; Daniele Fallin, M; Feinberg, Andrew P (2015-08-01). "Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort". International Journal of Epidemiology. 44 (4): 1199–1210. doi:10.1093/ije/dyv028. ISSN 0300-5771. PMC 4598797. PMID 25878217.
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