Aminolevulinate transaminase
| Aminolevulinate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.43 | ||||||||
| CAS no. | 9012-46-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Aminolevulinate transaminase (EC 2.6.1.43) is a pyridoxal phosphate-dependent enzyme that catalyzes the reversible chemical reaction
The two substrates of this enzyme characterised from Rhodopseudomonas spheroides are aminolevulinic acid and pyruvic acid. Its products are 4,5-dioxopentanoic acid and L-alanine.[1][2] Although aminolevulinic acid is an intermediate in the pathway to heme, via protoporphyrinogen IX, the main biosynthetic pathway to it in Rhodopseudomonas spheroides is via glycine and succinyl coenzyme A.[3]
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is 5-aminolevulinate:pyruvate aminotransferase. Other names in common use include aminolevulinate aminotransferase, gamma,delta-dioxovalerate, aminotransferase, gamma,delta-dioxovaleric acid transaminase, 4,5-dioxovalerate aminotransferase, 4,5-dioxovaleric acid transaminase, 4,5-dioxovaleric transaminase, 5-aminolevulinic acid transaminase, alanine-gamma,delta-dioxovalerate aminotransferase, alanine-dioxovalerate aminotransferase, alanine:4,5-dioxovalerate aminotransferase, aminolevulinic acid transaminase, dioxovalerate transaminase, L-alanine-4,5-dioxovalerate aminotransferase, L-alanine:4,5-dioxovaleric acid transaminase, L-alanine:dioxovalerate transaminase, DOVA transaminase, and 4,5-dioxovaleric acid aminotransferase.[4]
References
- ↑ Gibson KD, Matthew M, Neuberger A (1961). "Biosynthesis of porphyrins and chlorophylls". Nature. 192 (4799): 204–208. Bibcode:1961Natur.192..204G. doi:10.1038/192204a0. PMID 13898421. S2CID 41389926.
- ↑ Neuberger A, Turner JM (1963). "gamma,delta-Dioxovalerate aminotransferase activity in Rhodopseudomonas spheroides". Biochimica et Biophysica Acta. 67: 342–5. doi:10.1016/0006-3002(63)91839-0. PMID 13938132.
- ↑ Battersby, Alan R. (2000). "Tetrapyrroles: The pigments of life". Natural Product Reports. 17 (6): 507–526. doi:10.1039/B002635M. PMID 11152419.
- ↑ Enzyme 2.6.1.43 at KEGG Pathway Database.