Aminoacyl-tRNA hydrolase
| aminoacyl-tRNA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.29 | ||||||||
| CAS no. | 9054-98-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme aminoacyl-tRNA hydrolase (EC 3.1.1.29) catalyzes the reaction
- N-substituted aminoacyl-tRNA + H2O N-substituted amino acid + tRNA
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is aminoacyl-tRNA aminoacylhydrolase. Other names in common use include aminoacyl-transfer ribonucleate hydrolase, N-substituted aminoacyl transfer RNA hydrolase, and peptidyl-tRNA hydrolase.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1RYB, PDB: 1WN2, PDB: 1XTY, PDB: 2D3K, PDB: 2E1B, PDB: 2PTH, PDB: 2Z2I, PDB: 2Z2J, and PDB: 2Z2K.
References
- Jost JP, Bock RM (1969). "Enzymatic hydrolysis of N-substituted aminoacyl transfer ribonucleic acid in yeast". J. Biol. Chem. 244 (21): 5866–73. doi:10.1016/S0021-9258(18)63554-9. PMID 4981785.
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