Alistipes putredinis
| Alistipes putredinis | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Pseudomonadati |
| Phylum: | Bacteroidota |
| Class: | Bacteroidia |
| Order: | Bacteroidales |
| Family: | Rikenellaceae |
| Genus: | Alistipes |
| Species: | A. putredinis |
| Binomial name | |
| Alistipes putredinis (Weinberg et al. 1937) Rautio et al. 2003 | |
| Synonyms[1] | |
| |
Alistipes putredinis is a strictly anaerobic, gram-negative bacterium predominantly found in the gut of healthy individuals.[2] It has been identified as a core species of the human gut microbiota.[2] A. putredinis is present in more than 95% of individuals[2] and has gotten increased attention in recent years due to its roles in host metabolism and immunity.[3] It has been suggested that the bacterium can modulate the relationship between physical activity and body weight.[4][5] On top of this, A. putredinis abundance has been consistently reduced in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)[6]). This reduction shows a negative correlation with liver fibrosis progression; A. putredinis levels decline as fibrosis severity increases.[7]
Alistipes putredinis can be isolated from feces, abdominal and rectal abscesses, cases of acute appendicitis, foot rot in sheep, farm soil, and rarely from the human mouth.[8]
Cells
Alistipes putredinis cells are non-motile, straight or slightly curved slender rods. The cells have rounded ends, do not form spores, and usually occur alone or in pairs. A. putredinis cell dimensions are 0.3-0.5 by 0.9-3.0 μm.[8] The bacterium's optimum temperature is 37 °C, with most strains frowing between 25-45 °C.
Cells produce fibrinolysin and indole, and are sensitive to clindamycin, cefoxitin, chloramphenicol, erythromycin and metronidazole.[8]
MASLD
After isolating A. putredinis from the feces of a healthy Chinese adult, a 2025 study describes alleviates hepatic lipid accumulation, inflammation, and gut microbiota dysbiosis in rats with MASLD.[9] The researchers suggest A. putredinis may help ameliorate metabolic and inflammatory disturbances associated with MASLD.[9]
Alistipes putredinis may also contribute to metabolic health by supporting gut barrier function and modulating immune responses.[10][11] The bacterium also exhibits anti-inflammatory properties and was shown to alleviate inflammatory bowel disease in murine models.[12]
References
- ↑ Alistipes putredinis in LPSN; Parte, Aidan C.; Sardà Carbasse, Joaquim; Meier-Kolthoff, Jan P.; Reimer, Lorenz C.; Göker, Markus (1 November 2020). "List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ". International Journal of Systematic and Evolutionary Microbiology. 70 (11): 5607–5612. doi:10.1099/ijsem.0.004332.
- 1 2 3 Gacesa, R.; Kurilshikov, A.; Vich Vila, A.; Sinha, T.; Klaassen, M. A. Y.; Bolte, L. A.; Andreu-Sánchez, S.; Chen, L.; Collij, V.; Hu, S.; Dekens, J. A. M.; Lenters, V. C.; Björk, J. R.; Swarte, J. C.; Swertz, M. A. (2022-04-13). "Environmental factors shaping the gut microbiome in a Dutch population". Nature. 604 (7907): 732–739. Bibcode:2022Natur.604..732G. doi:10.1038/s41586-022-04567-7. ISSN 0028-0836. PMID 35418674.
- ↑ Parker, Bianca J.; Wearsch, Pamela A.; Veloo, Alida C. M.; Rodriguez-Palacios, Alex (2020-06-09). "The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health". Frontiers in Immunology. 11 906. doi:10.3389/fimmu.2020.00906. ISSN 1664-3224. PMC 7296073. PMID 32582143.
- ↑ Takeuchi, Tadashi; Kubota, Tetsuya; Nakanishi, Yumiko; Tsugawa, Hiroshi; Suda, Wataru; Kwon, Andrew Tae-Jun; Yazaki, Junshi; Ikeda, Kazutaka; Nemoto, Shino; Mochizuki, Yoshiki; Kitami, Toshimori; Yugi, Katsuyuki; Mizuno, Yoshiko; Yamamichi, Nobutake; Yamazaki, Tsutomu (2023-08-30). "Gut microbial carbohydrate metabolism contributes to insulin resistance". Nature. 621 (7978): 389–395. Bibcode:2023Natur.621..389T. doi:10.1038/s41586-023-06466-x. ISSN 0028-0836. PMC 10499599. PMID 37648852.
- ↑ Wang, Kai; Mehta, Raaj S.; Ma, Wenjie; Nguyen, Long H.; Wang, Dong D.; Ghazi, Andrew R.; Yan, Yan; Al-Shaar, Laila; Wang, Yiqing; Hang, Dong; Fu, Benjamin C.; Ogino, Shuji; Rimm, Eric B.; Hu, Frank B.; Carmody, Rachel N. (2023-05-30). "The gut microbiome modifies the associations of short- and long-term physical activity with body weight changes". Microbiome. 11 (1) 121. doi:10.1186/s40168-023-01542-w. ISSN 2049-2618. PMC 10228038. PMID 37254152.
- ↑ Yang, Chao; Xu, Jianguo; Xu, Xiaomin; Xu, Wen; Tong, Bangzhuo; Wang, Shulin; Ji, Rujie; Tan, Yan; Zhu, Ying (2023-06-20). "Characteristics of gut microbiota in patients with metabolic associated fatty liver disease". Scientific Reports. 13 (1) 9988. Bibcode:2023NatSR..13.9988Y. doi:10.1038/s41598-023-37163-4. ISSN 2045-2322. PMC 10281992. PMID 37340081.
- ↑ Shao, Li; Ling, Zongxin; Chen, Deying; Liu, Yufeng; Yang, Fengling; Li, Lanjuan (2018-12-18). "Disorganized Gut Microbiome Contributed to Liver Cirrhosis Progression: A Meta-Omics-Based Study". Frontiers in Microbiology. 9 3166. doi:10.3389/fmicb.2018.03166. ISSN 1664-302X. PMC 6315199. PMID 30631318.
- 1 2 3 Rautio, Merja; Eerola, Erkki; Väisänen-Tunkelrott, Marja-Liisa; Molitoris, Denise; Lawson, Paul; Collins, Matthew D.; Jousimies-Somer, Hannele (2003). "Reclassification of Bacteroides putredinis (Weinberg et al., 1937) in a New Genus Alistipes gen. nov., as Alistipes putredinis comb. nov., and Description of Alistipes finegoldii sp. nov., from Human Sources". Systematic and Applied Microbiology. 26 (2): 182–188. Bibcode:2003SyApM..26..182R. doi:10.1078/072320203322346029. ISSN 0723-2020. PMID 12866844.
- 1 2 Zhang, Shuwei; Wang, Ruoshi; Zhao, Ruiqing; Lu, Yao; Xu, Mingchao; Lin, Xiaoying; Lan, Ruiting; Zhang, Suping; Tang, Huijing; Fan, Qianhua; Yang, Jing; Liu, Liyun; Xu, Jianguo (2025-06-16). "Alistipes putredinis Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats via Gut Microbiota Remodeling and Inflammatory Suppression". Nutrients. 17 (12): 2013. doi:10.3390/nu17122013. ISSN 2072-6643. PMC 12196099. PMID 40573124.
- ↑ Yang, Yapeng; Zheng, Xiaojiao; Wang, Yuqing; Tan, Xiang; Zou, Huicong; Feng, Shuaifei; Zhang, Hang; Zhang, Zeyue; He, Jinhui; Cui, Bota; Zhang, Xueying; Wu, Zhifeng; Dong, Miaomiao; Cheng, Wei; Tao, Shiyu (2022-02-14). "Human Fecal Microbiota Transplantation Reduces the Susceptibility to Dextran Sulfate Sodium-Induced Germ-Free Mouse Colitis". Frontiers in Immunology. 13 836542. doi:10.3389/fimmu.2022.836542. ISSN 1664-3224. PMC 8882623. PMID 35237276.
- ↑ Zhu, Lixin; Baker, Susan S.; Gill, Chelsea; Liu, Wensheng; Alkhouri, Razan; Baker, Robert D.; Gill, Steven R. (February 2013). "Characterization of Gut Microbiomes in Nonalcoholic Steatohepatitis (NASH) Patients: A Connection Between Endogenous Alcohol and NASH". Hepatology. 57 (2): 601–609. doi:10.1002/hep.26093. ISSN 0270-9139. PMID 23055155.
- ↑ Ishikawa, Dai; Zhang, Xiaochen; Nomura, Kei; Shibuya, Tomoyoshi; Hojo, Mariko; Yamashita, Makoto; Koizumi, Satoshi; Yamazaki, Fuhito; Iwamoto, Susumu; Saito, Masato; Kunigo, Keisuke; Nakano, Ryosuke; Honma, Nakayuki; Urakawa, Itaru; Nagahara, Akihito (2024-05-11). "Anti-inflammatory Effects of Bacteroidota Strains Derived From Outstanding Donors of Fecal Microbiota Transplantation for the Treatment of Ulcerative Colitis". Inflammatory Bowel Diseases. 30 (11): 2136–2145. doi:10.1093/ibd/izae080. ISSN 1078-0998. PMID 38733623.