Alistipes onderdonkii

Alistipes onderdonkii
Scientific classification Edit this classification
Domain: Bacteria
Kingdom: Pseudomonadati
Phylum: Bacteroidota
Class: Bacteroidia
Order: Bacteroidales
Family: Rikenellaceae
Genus: Alistipes
Species:
A. onderdonkii
Binomial name
Alistipes onderdonkii
Song et al. 2006[1]
Type strain[2]
ATCC BAA-1178, CCUG 48946, DSM 19147, JCM 16771, WAL 8169

Alistipes onderdonkii is a Gram-negative, rod-shaped and anaerobic bacterium from the genus Alistipes.[1][3][4][5][6] It was first discovered in 2006, isolated from abdominal abscess faeces and appendix tissue [7] in the United States.[1][3][4][5][6] It is typically part of a healthy human gut microbiota[8] and has also been found in sheep, goats and wild mouflons.[9]

This species was named after microbiologist Andrew. B Onderdonk to pay homage to his contribution to intestinal microbiota and anaerobic bacteria.[7] In 2020 it was split into two sub species A. onderdonkii subsp. vulgaris and A. onderdonkii subsp. Onderdonkii.[10]

Description

  • Rod shaped cells with rounded edges.
  • 0.2-0.5 x 0.5 - 3 µm in size
  • With 48h anaerobic incubation at 37 °C with supplementation of brucella blood agar colonies are circular, convex, entire, grey, opaque weakly b-haemolytic and 0.5-0.8mm in diameter.
  • Colonies will appear black while incubated for 4 days on laked rabbit blood agar
  • Under UV light (365 nm) colonies are brown with no fluorescence

Health

Records of A. onderdonkii causing infection in humans is very rare, with the first report occurring in 2006.[11][7] The first confirmed case by 16S RNA analysis was in February 2020 where a severe infection was caused in a 58 year old man.[11] Resistance to the antibiotics penicillin and moxifloxacin was noted in this case, but was successfully treated with meropenem, metronidazole and surgery.[11]

In a study on mice and A. onderonkii has been shown to be able to reduce tumour necrosis factor production, which in excessive amounts can cause damage to skin grafts, and therefore suggesting this species could be beneficial for skin graft survival.[12]

The ability of A. onderonkii as a protective agent in radiotherapy treatment has been investigated. After radiation exposure to the intestines of mice, the administration of A. onderdonkii reduced intestinal damage and significantly improved survival.[13]

A. onderonkii has been correlated with durable clinical benefits (a medical term for a cancer treatments ability to slow or halt disease progression typically longer than 6 months) in patients with lung cancer.[14]

References

  1. 1 2 3 "Alistipes". LPSN.
  2. ↑ "Alistipes onderdonkii Taxon Passport - StrainInfo". www.straininfo.net. Archived from the original on 2019-02-20. Retrieved 2019-02-20.
  3. 1 2 "Alistipes onderdonkii". www.uniprot.org.
  4. 1 2 Parker, Charles Thomas; Garrity, George M (1 August 2008). Parker, Charles Thomas; Garrity, George M (eds.). "Taxonomic Abstract for the species". NamesforLife, LLC. doi:10.1601/tx.10265. {{cite journal}}: Cite journal requires |journal= (help)
  5. 1 2 "Details: DSM-19147". www.dsmz.de.
  6. 1 2 Song, Y; Könönen, E; Rautio, M; Liu, C; Bryk, A; Eerola, E; Finegold, SM (August 2006). "Alistipes onderdonkii sp. nov. and Alistipes shahii sp. nov., of human origin". International Journal of Systematic and Evolutionary Microbiology. 56 (Pt 8): 1985–90. doi:10.1099/ijs.0.64318-0. PMID 16902041.
  7. 1 2 3 Song, Yuli; Könönen, Eija; Rautio, Merja; Liu, Chengxu; Bryk, Anne; Eerola, Erkki; Finegold, Sydney M. (2006-08-01). "Alistipes onderdonkii sp. nov. and Alistipes shahii sp. nov., of human origin". International Journal of Systematic and Evolutionary Microbiology. 56 (8): 1985–1990. doi:10.1099/ijs.0.64318-0. ISSN 1466-5026.
  8. ↑ Li, Zhipeng; Rasic, Mladen; Kwan, Montserrat; Sepulveda, Martin; McIntosh, Christine; Shastry, Vivaswat; Chen, Luqiu; Finn, Patricia; Perkins, David; Alegre, Maria-Luisa (February 2023). "Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival". American Journal of Transplantation. 23 (2): 272–277. doi:10.1016/j.ajt.2022.11.011. PMC 10041932. PMID 36804134.
  9. ↑ Hasapis, Kyriacos A.; Charalambidou, Iris; Phanis, Catherine O. 'Dowd; Kazamia, Stefanie; Kassinis, Nicolaos; Schou, Chad; Karanis, Panagiotis (2024-12-01). "First detection and molecular characterization of Alistipes onderdonkii in ruminants". The Microbe. 5 100205. doi:10.1016/j.microb.2024.100205. ISSN 2950-1946.
  10. ↑ Sakamoto, Mitsuo; Ikeyama, Nao; Ogata, Yusuke; Suda, Wataru; Iino, Takao; Hattori, Masahira; Ohkuma, Moriya (2020). "Alistipes communis sp. nov., Alistipes dispar sp. nov. and Alistipes onderdonkii subsp. vulgaris subsp. nov., isolated from human faeces, and creation of Alistipes onderdonkii subsp. onderdonkii subsp. nov". International Journal of Systematic and Evolutionary Microbiology. 70 (1): 473–480. doi:10.1099/ijsem.0.003778. ISSN 1466-5034.
  11. 1 2 3 "First description of abdominal infection due to Alistipes onderdonkii". Anaerobe. 66 102283. 2020-12-01. doi:10.1016/j.anaerobe.2020.102283. ISSN 1075-9964.
  12. ↑ Li, Zhipeng; Rasic, Mladen; Kwan, Montserrat; Sepulveda, Martin; McIntosh, Christine; Shastry, Vivaswat; Chen, Luqiu; Finn, Patricia; Perkins, David; Alegre, Maria-Luisa (February 2023). "Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival". American Journal of Transplantation. 23 (2): 272–277. doi:10.1016/j.ajt.2022.11.011. ISSN 1600-6135. PMC 10041932. PMID 36804134.
  13. ↑ Yu, Yeuni; Park, Sun; Jeon, Jaewan; Lee, Se-Hui; Kim, Hyeyun; Seo, Dongju; Park, Minwoo; Park, Eunho; Kim, Ji Young; Cho, Seong-Jun; Jo, Sunmi; Park, Geumju; Yang, Jin-Young (2025-06-18). "The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer". Discover Oncology. 16 (1): 1142. doi:10.1007/s12672-025-02992-4. ISSN 2730-6011. PMC 12177120. PMID 40531331.
  14. ↑ Haberman, Yael; Kamer, Iris; Amir, Amnon; Goldenberg, Sapir; Efroni, Gilat; Daniel-Meshulam, Inbal; Lobachov, Anastasiya; Daher, Sameh; Hadar, Rotem; Gantz-Sorotsky, Hadas; Urban, Damien; Braun, Tzipi; Bar, Jair (2023-02-03). "Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit". Scientific Reports. 13 (1): 2007. doi:10.1038/s41598-023-29136-4. ISSN 2045-2322. PMC 9898251. PMID 36737654.{{cite journal}}: CS1 maint: unflagged free DOI (link)
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