Akkermansia massiliensis
| Akkermansia massiliensis | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Pseudomonadati |
| Phylum: | Verrucomicrobiota |
| Class: | Verrucomicrobiia |
| Order: | Verrucomicrobiales |
| Family: | Akkermansiaceae |
| Genus: | Akkermansia |
| Species: | A. massiliensis |
| Binomial name | |
| Akkermansia massiliensis Ndongo et al. 2025 | |
Akkermansia massiliensis is an obligately anaerobic, Gram-negative, motile species of bacteria in the human gut microbiome.[1] The bacterium is non-spore-forming and cells are rod-shaped.[1] The type strain is Marseille-P6666T (= CSUR P6666 = CECT 30548).[1] The species is named for the city of Marseille, where it was first isolated from human feces in 2022.[1]
Role in the human gut microbiome
Akkermansia massiliensis is the second most prevalent species of Akkermansia in the human gut microbiome, after A. municiphila.[2] A. massiliensis has been shown to degrade extracellular ATP in the gut, which reduces inflammation.[3] In addition, A. massiliensis has been shown to produce agmatine at a higher rate than other Akkermansia species.[3] A. massiliensis is tolerant to bile and gastric juice pH conditions.[4] When rats were exposed to high levels of A. massiliensis, no negative consequences were seen and there was no evidence of virulence.[4]
Interaction with multiple sclerosis
There is some evidence that low levels of A. massiliensis in the human gut microbiome is correlated with a higher incidence of multiple sclerosis (MS).[5]
References
- 1 2 3 4 Ndongo, Sokhna; Armstrong, Nicholas; Raoult, Didier; Fournier, Pierre-Edouard (2022-12-16). "Reclassification of eight Akkermansia muciniphila strains and description of Akkermansia massiliensis sp. nov. and Candidatus Akkermansia timonensis, isolated from human feces". Scientific Reports. 12 (1): 21747. Bibcode:2022NatSR..1221747N. doi:10.1038/s41598-022-25873-0. ISSN 2045-2322. PMC 9758162. PMID 36526682.
- ↑ Kumar, Ritesh; Hasselwander, Oliver; Kane, Helene; Hibberd, Ashley A. (2024). "Akkermansia beyond muciniphila - emergence of new species Akkermansia massiliensis sp. nov". Microbiome Research Reports. 3 (3): 37. doi:10.20517/mrr.2024.28. ISSN 2771-5965. PMC 11480723. PMID 39421258.
- 1 2 Ritesh, Kumar; Helene, Kane; Qiong, Wang; Ashley, Hibberd; Max, Jensen, Henrik; Hye-Sook, Kim; Yde, Bak, Steffen; Isabelle, Auzanneau; Stéphanie, Bry; Niels, Christensen; Andrew, Friedman; Pia, Rasinkangas; C., Ouwehand, Arthur; D., Forssten, Sofia; Oliver, Hasselwander (January 2022). "Identification and Characterization of a Novel Species of Genus Akkermansia with Metabolic Health Effects in a Diet-Induced Obesity Mouse Model". Cells. 11 (13). doi:10.3390/cell (inactive 7 August 2026). ISSN 2073-4409. Archived from the original on 2024-11-12.
{{cite journal}}: CS1 maint: DOI inactive as of August 2026 (link) CS1 maint: multiple names: authors list (link) - 1 2 Pitt, Jeffrey; Bauter, Mark R.; Kumar, Ritesh; Hasselwander, Oliver; Hibberd, Ashley A.; Kane, Helene; Wang, Qiong; Auzanneau, Isabelle; Bry, Stéphanie; David, Elisabeth; Seguinot, Pauline; Burns, Frank; Smith, Amy B. (2025-06-01). "Safety evaluation of Akkermansia massiliensis sp. nov. DSM 33459". Toxicology Reports. 14 102042. Bibcode:2025ToxR...1402042P. doi:10.1016/j.toxrep.2025.102042. ISSN 2214-7500. PMC 12146011. PMID 40491581.
- ↑ Orrù, Valeria; Marongiu, Michele; Cocco, Eleonora; Zoledziewska, Magdalena (August 2026). "Potential role of Akkermansia massiliensis in multiple sclerosis protection by the FcRL3 gene". Genes & Immunity. 27 (4): 487–493. doi:10.1038/s41435-026-00404-3. ISSN 1476-5470. PMID 42436285.