Aditoprim

Aditoprim
Names
	Preferred IUPAC name 5-{[4-(Dimethylamino)-3,5-dimethoxyphenyl]methyl}pyrimidine-2,4-diamine
Identifiers
CAS Number	56066-63-8 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL293299;
ChemSpider	62000;
PubChem CID	68755;
UNII	2Z81WDX2ZH ;
CompTox Dashboard (EPA)	DTXSID90204616 ;
	InChI InChI=1S/C15H21N5O2/c1-20(2)13-11(21-3)6-9(7-12(13)22-4)5-10-8-18-15(17)19-14(10)16/h6-8H,5H2,1-4H3,(H4,16,17,18,19) Key: QBQMXWZTRRWPGK-UHFFFAOYSA-N; InChI=1/C15H21N5O2/c1-20(2)13-11(21-3)6-9(7-12(13)22-4)5-10-8-18-15(17)19-14(10)16/h6-8H,5H2,1-4H3,(H4,16,17,18,19) Key: QBQMXWZTRRWPGK-UHFFFAOYAE;
	SMILES CN(C)C1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC;
Properties
Chemical formula	C15H21N5O2
Molar mass	303.366 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Aditoprim is an antibacterial dihydrofolate reductase inhibitor.^[1] It is currently being investigated for veterinary use, mostly in China for the treatment of various Streptococcus caused conditions.^[2]^[3] A 2025 study found that it is toxic to the human gut microbiota as most antibiotics are, and established a microbiologically acceptable daily intake of 91.67 µg/kg.BW/day.^[4]

References

↑ Then, RL; Keller, M (1988). "Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor". Zentralblatt für Veterinärmedizin Reihe B. 35 (2): 114–20. doi:10.1111/j.1439-0450.1988.tb00476.x. PMID 3420982.
↑ Cheng, Guyue; Xu, Yamei; Zhu, Xudong; Xie, Shuyu; Wang, Liye; Huang, Lingli; Hao, Haihong; Liu, Zhenli; Pan, Yuanhu; Chen, Dongmei; Wang, Yulian; Yuan, Zonghui (2017-02-01). "The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis". Scientific Reports. 7 (1). doi:10.1038/srep41370. ISSN 2045-2322. PMC 5286432. PMID 28145487.
↑ Mi, Kun; Sun, Lei; Zhang, Lan; Tang, Aoran; Tian, Xiaoyuan; Hou, Yixuan; Sun, Lingling; Huang, Lingli (2024-04-17). "A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis". Frontiers in Pharmacology. 15. ISSN 1663-9812. PMC 11061430. PMID 38694922.
↑ Wang, Junhao; Liu, Chunbei; Gu, Fangtong; Gu, Yufeng; Hao, Haihong (2025-12-01). "Microbiological toxicology of the new antibiotic aditoprim on human intestinal microbiota". Toxicology Letters. 414. doi:10.1016/j.toxlet.2025.111780. ISSN 0378-4274.

[1] Then, RL; Keller, M (1988). "Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor". Zentralblatt für Veterinärmedizin Reihe B. 35 (2): 114–20. doi:10.1111/j.1439-0450.1988.tb00476.x. PMID 3420982.

[2] Cheng, Guyue; Xu, Yamei; Zhu, Xudong; Xie, Shuyu; Wang, Liye; Huang, Lingli; Hao, Haihong; Liu, Zhenli; Pan, Yuanhu; Chen, Dongmei; Wang, Yulian; Yuan, Zonghui (2017-02-01). "The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis". Scientific Reports. 7 (1). doi:10.1038/srep41370. ISSN 2045-2322. PMC 5286432. PMID 28145487.

[3] Mi, Kun; Sun, Lei; Zhang, Lan; Tang, Aoran; Tian, Xiaoyuan; Hou, Yixuan; Sun, Lingling; Huang, Lingli (2024-04-17). "A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis". Frontiers in Pharmacology. 15. ISSN 1663-9812. PMC 11061430. PMID 38694922.

[4] Wang, Junhao; Liu, Chunbei; Gu, Fangtong; Gu, Yufeng; Hao, Haihong (2025-12-01). "Microbiological toxicology of the new antibiotic aditoprim on human intestinal microbiota". Toxicology Letters. 414. doi:10.1016/j.toxlet.2025.111780. ISSN 0378-4274.

[1]

[2]

[3]

[4]