Acetyl-CoA carboxytransferase
| Acetyl-CoA carboxytransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 The enzyme as folded by AlphaFold | |||||||||
| Identifiers | |||||||||
| EC no. | 2.1.3.15 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Acety-CoA carboxytransferase (known also as accAD and N6-carboxybiotinyl-L-lysine:acetyl-CoA:carboxytransferase) is a transferase enzyme that catalyses the transfer of a carboxyl group from a biotinylated biotin carboxyl carrier protein (abbrev. BCCP) to acetyl coenzyme A, yielding malonyl-CoA.[1] In some species, this is part of a multi-domain protein that also has the carrier protein as well as biotin carboxylase. Some enzymes can also carry out the carboxylation of propanonyl-CoA and butanoyl-CoA. The enzyme catalyzes the following reaction,
The enzyme characterised from Acidianus brierleyi is involved in several biochemical pathways, including the 3-hydroxypropanoate cycle, 4-hydroxybutanate cycle, the assembly of biotin-carboxyl carrier proteins, candicidin biosynthesis, fatty acid biosynthesis and glyoxylate assimilation.[2][3]
References
- ↑ Enzyme 2.1.3.15 at KEGG Pathway Database.
- ↑ Bilder, Patrick; Lightle, Sandra; Bainbridge, Graeme; Ohren, Jeffrey; Finzel, Barry; Sun, Fang; Holley, Susan; Al-Kassim, Loola; Spessard, Cindy; Melnick, Michael; Newcomer, Marcia; Waldrop, Grover L. (2006). "The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme,". Biochemistry. 45 (6): 1712–1722. doi:10.1021/bi0520479. PMID 16460018.
- ↑ Chuakrut, Songkran; Arai, Hiroyuki; Ishii, Masaharu; Igarashi, Yasuo (2003). "Characterization of a Bifunctional Archaeal Acyl Coenzyme a Carboxylase". Journal of Bacteriology. 185 (3): 938–947. doi:10.1128/JB.185.3.938-947.2003. PMC 142822. PMID 12533469.