AXC-715

AXC-715
Identifiers
	IUPAC name 1-(4-aminobutyl)-2-butylimidazo[4,5-c]quinolin-4-amine;
CAS Number	313350-31-1;
PubChem CID	15538226;
ChEMBL	ChEMBL5614119;
Chemical and physical data
Formula	C18H25N5
Molar mass	311.433 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCC1=NC2=C(N1CCCCN)C3=CC=CC=C3N=C2N;
	InChI InChI=1S/C18H25N5/c1-2-3-10-15-22-16-17(23(15)12-7-6-11-19)13-8-4-5-9-14(13)21-18(16)20/h4-5,8-9H,2-3,6-7,10-12,19H2,1H3,(H2,20,21); Key:IGZKWNHHWYBLOU-UHFFFAOYSA-N;

AXC-715 is a drug which acts as an agonist at Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8), with modest selectivity for TLR7. It acts as an immunostimulant, and has broad spectrum antiviral effects in animal models, and is also of interest as a potential anti-cancer drug.^[1]^[2]

References

↑ Xi M, Zhu J, Zhang F, Shen H, Chen J, Xiao Z, et al. (2024). "Antibody-drug conjugates for targeted cancer therapy: Recent advances in potential payloads". European Journal of Medicinal Chemistry. 276 116709. doi:10.1016/j.ejmech.2024.116709. PMID 39068862.
↑ Yao C, Du M, Ma Y, Wang H, Hang L, Li Z, et al. (2026). "A Novel Small-Molecule TLR7 Agonist AXC-715 Stabilizes TLR7 Dimerization and Exhibits Broad-Spectrum Antiviral Activity". Microorganisms. 14 (4): 862. doi:10.3390/microorganisms14040862. PMC 13118833. PMID 42075261.

[1] Xi M, Zhu J, Zhang F, Shen H, Chen J, Xiao Z, et al. (2024). "Antibody-drug conjugates for targeted cancer therapy: Recent advances in potential payloads". European Journal of Medicinal Chemistry. 276 116709. doi:10.1016/j.ejmech.2024.116709. PMID 39068862.

[2] Yao C, Du M, Ma Y, Wang H, Hang L, Li Z, et al. (2026). "A Novel Small-Molecule TLR7 Agonist AXC-715 Stabilizes TLR7 Dimerization and Exhibits Broad-Spectrum Antiviral Activity". Microorganisms. 14 (4): 862. doi:10.3390/microorganisms14040862. PMC 13118833. PMID 42075261.

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