Phosphoribosylaminoimidazolecarboxamide formyltransferase
| Phosphoribosylaminoimidazolecarboxamide formyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.2.3 | ||||||||
| CAS no. | 9032-03-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3), also known by the shorter name AICAR transformylase, is an enzyme that catalyzes the chemical reaction
This tetrahydrofolate–dependent enzyme catalyzes a nucleophilic acyl substitution of the formyl group from the cofactor 10-formyltetrahydrofolate (10-CHO-THF) to AICA ribonucleotide to give 5-formamidoimidazole-4-carboxamide ribotide (FAICAR). This reaction is involved in purine metabolism.[1]
Nomenclature
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:5-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase. Other names in common use include:[2]
- 10-formyltetrahydrofolate:5-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase
- 5-amino-1-ribosyl-4-imidazolecarboxamide 5-phosphate,
- 5-amino-4-imidazolecarboxamide ribonucleotide transformylase,
- 5-amino-4-imidazolecarboxamide ribotide transformylase,
- 5-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase,
- AICAR formyltransferase,
- AICAR transformylase,
- aminoimidazolecarboxamide ribonucleotide transformylase, and
- transformylase,
- bifunctional purine biosynthesis protein PURH,
- ATIC.
Structural studies
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1G8M, PDB: 1M9N, PDB: 1OZ0, PDB: 1P4R, PDB: 1PKX, PDB: 1PL0, PDB: 1THZ, PDB: 2B1G, PDB: 2B1I, PDB: 2IU0, and PDB: 2IU3.
References
- ↑ Hartman SC, Buchanan JM (1959). "Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reactions". J. Biol. Chem. 234 (7): 1812–6. doi:10.1016/S0021-9258(18)69931-4. PMID 13672969.
- ↑ Enzyme 2.1.2.3 at KEGG Pathway Database.
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