6-hydroxymellein O-methyltransferase
| 6-hydroxymellein O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.108 | ||||||||
| CAS no. | 124149-02-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
6-hydroxymellein O-methyltransferase (EC 2.1.1.108) is an enzyme that catalyzes the chemical reaction
-6-hydroxymellein.svg.png)
-6-methoxymellein.svg.png)
This is a methylation reaction in which the dihydroisocoumarin, (R)-6-hydroxymellein, is converted to the phytoalexin, (R)-6-methoxymellein. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from carrots.[1][2][3]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase. This enzyme is also called 6-hydroxymellein methyltransferase.[4]
References
- ↑ Kurosaki F, Nishi A (1988). "A methyltransferase for synthesis of the phytoalexin 6-methoxymellein in carrot cells". FEBS Lett. 227 (2): 183–186. Bibcode:1988FEBSL.227..183K. doi:10.1016/0014-5793(88)80894-9.
- ↑ Kurosaki, Fumiya; Nishi, Arasuke (1991). "Comparison of enzyme activities involved in the biosynthesis of carrot phytoalexin 6-methoxymellein". Phytochemistry. 30 (6): 1823–1825. doi:10.1016/0031-9422(91)85021-Q.
- ↑ "Induction and regulation of biosynthetic activity of phytoalexin in carrot cells". Bioactive Natural Products (Part F). Studies in Natural Products Chemistry. Vol. 25. 2001. pp. 483–512. doi:10.1016/S1572-5995(01)80016-8. ISBN 978-0-08-044001-9.
- ↑ Enzyme 2.1.1.108 at KEGG Pathway Database.
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