6-Deoxy-5-ketofructose 1-phosphate synthase
| 6-deoxy-5-ketofructose 1-phosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.2.1.11 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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6-deoxy-5-ketofructose 1-phosphate synthase (EC 2.2.1.11, DKFP synthase, MJ1585 (gene)) is an enzyme with systematic name 2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase.[1] It catalyses two related chemical reactions. Both form 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate (6-deoxy-5-ketofructose 1-phosphate) from a fructose phosphate starting material.[2][3] In one reaction, fructose-1,6-diphosphate is combined with methylglyoxal:
+
+
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
Alternatively, fructose 6-phosphate and methylglyoxal give the same main product but with D-glyceraldehyde as byproduct. This enzyme, characterised from Methanocaldococcus jannaschii is part of a pathway for the biosynthesis of 3-dehydroquinate,[3] and hence aromatic amino acids.[1]
References
- 1 2 Enzyme 2.2.1.11 at KEGG Pathway Database.
- ↑ White RH, Xu H (October 2006). "Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii". Biochemistry. 45 (40): 12366–79. doi:10.1021/bi061018a. PMID 17014089.
- 1 2 Samland AK, Wang M, Sprenger GA (April 2008). "MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity". FEMS Microbiology Letters. 281 (1): 36–41. doi:10.1111/j.1574-6968.2008.01079.x. PMID 18318840.
External links
- 6-deoxy-5-ketofructose+1-phosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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