4-pyridoxolactonase
| 4-pyridoxolactonase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.27 | ||||||||
| CAS no. | 37278-41-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
4-pyridoxolactonase (EC 3.1.1.27) is an enzyme that catalyzes the reaction
4-pyridoxolactone
H2O
4-pyridoxic acid
The enzyme characterised from Pseudomonas species and Mesorhizobium loti hydrolyses 4-pyridoxolactone to 4-pyridoxic acid.[1] Its structure has been determined by X-ray crystallography.[2] The reaction is part of the breakdown of vitamin B6 and pyridoxine.[3]
This enzyme is a hydrolase, specifically one acting on carboxylic ester bonds. The systematic name is 4-pyridoxolactone lactonohydrolase.[4]
References
- ↑ Burg, R. W.; Snell, E. E. (1969). "The Bacterial Oxidation of Vitamin B6". Journal of Biological Chemistry. 244 (10): 2585–2589. doi:10.1016/S0021-9258(18)83440-8.
- ↑ Kobayashi, Jun; Yoshikane, Yu; Yagi, Toshiharu; et al. (2014). "Structure of 4-pyridoxolactonase from Mesorhizobium loti". Acta Crystallographica Section F Structural Biology Communications. 70 (4): 424–432. doi:10.1107/S2053230X14003926. PMC 3976056. PMID 24699732.
- ↑ Funami, Junichi; Yoshikane, Yu; Kobayashi, Hitoshi; et al. (2005). "4-Pyridoxolactonase from a symbiotic nitrogen-fixing bacterium Mesorhizobium loti: Cloning, expression, and characterization". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1753 (2): 234–239. doi:10.1016/j.bbapap.2005.08.026. PMID 16226926.
- ↑ Enzyme 3.1.1.27 at KEGG Pathway Database.
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