4-nitrophenylphosphatase
| 4-nitrophenylphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.41 | ||||||||
| CAS no. | 9073-68-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
4-Nitrophenylphosphatase (EC 3.1.3.41) is an enzyme that catalyzes the reaction:
The enzyme characterised from baker's yeast hydrolyses 4-nitrophenyl phosphate to 4-nitrophenol and orthophosphate.[1][2][3] The enzyme interacts with amyloid precursor protein.[4][5]
This enzyme is a hydrolase, specifically one that acts on phosphoric monoester bonds. The systematic name of this enzyme class is 4-nitrophenylphosphate phosphohydrolase. Other names for this enzyme include nitrophenyl phosphatase, p-nitrophenylphosphatase, para-nitrophenyl phosphatase, K-pNPPase, NPPase, PNPPase, ecto-p-nitrophenyl phosphatase, and p-nitrophenylphosphate phosphohydrolase.[6]
Structural studies
As of late 2007, only one three-dimensional structure had been determined for this class of enzymes. The structure is available in the Protein Data Bank (PDB) under the accession code 1VJR.
References
- ↑ Attias J, Bonnet JL (1972). "A specific alkaline p-nitrophenylphosphatase activity from baker's yeast". Biochim. Biophys. Acta. 268 (2): 422–30. doi:10.1016/0005-2744(72)90338-5. PMID 4554643.
- ↑ Attias J, Durand H (1973). "Further characterization of a specific p-nitrophenylphosphatase from baker's yeast". Biochim. Biophys. Acta. 321 (2): 561–8. doi:10.1016/0005-2744(73)90199-x. PMID 4357666.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "4-Nitrophenylphosphatase". Enzyme Handbook 3. pp. 481–486. doi:10.1007/978-3-642-76463-9_102. ISBN 978-3-642-48962-4.
- ↑ Tummala, Hemachand; Li, Xiaofan; Homayouni, Ramin (2010). "Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family". European Journal of Neuroscience. 31 (11): 1926–1934. doi:10.1111/j.1460-9568.2010.07248.x. PMID 20497468.
- ↑ Yamamoto, Soh; Ogasawara, Noriko; Mitsuhashi, Yukari; Takano, Kenichi; Yokota, Shin-Ichi (2024). "The clarithromycin-binding proteins NIPSNAP1 and 2 regulate cytokine production through mitochondrial quality control". Scientific Reports. 14 (1) 2354. doi:10.1038/s41598-024-52582-7. PMC 10824736. PMID 38287119.
- ↑ Enzyme 3.1.3.41 at KEGG Pathway Database.