4-hydroxyglutamate transaminase
| 4-hydroxyglutamate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.23 | ||||||||
| CAS no. | 37277-86-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
4-hydroxyglutamate transaminase (EC 2.6.1.23) is an enzyme that catalyzes the reversible chemical reaction
-4-hydroxy-L-glutamic_acid.svg.png)
(4R)-4-hydroxy-L-glutamic acid
+
D-4-hydroxy-2-oxoglutaric acid
+
The two substrates of this enzyme characterised from rat liver are (4R)-4-hydroxy-L-glutamic acid and α-ketoglutaric acid. Its products are D-4-hydroxy-2-oxoglutaric acid and L-glutamic acid.[1][2] It has been suggested that this enzyme is the same as aspartate transaminase.[3]
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is 4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase. This enzyme is also called 4-hydroxyglutamate aminotransferase. It participates in arginine and proline metabolism.[4]
References
- ↑ Goldstone, Alfred; Adams, Elijah (1962). "Metabolism of γ-Hydroxyglutamic Acid". Journal of Biological Chemistry. 237 (11): 3476–3485. doi:10.1016/S0021-9258(19)70842-4.
- ↑ Kuratomi, Kazuoki; Fukunaga, Keiko; Kobayashi, Yasuko (1963). "The metabolism of γ-hydroxyglutamate in rat liver II. A transaminase concerned in γ-hydroxyglutamate metabolism". Biochimica et Biophysica Acta. 78 (4): 629–636. doi:10.1016/0006-3002(63)91028-X. PMID 14089443.
- ↑ Maitra, Umadas; Dekker, Eugene E. (1964). "Purification of rat-liver γ-hydroxyglutamate transminase and its probable identity with glutamate-aspartate transminase". Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects. 81 (3): 517–532. doi:10.1016/0926-6569(64)90136-1. hdl:2027.42/32138. PMID 14170323.
- ↑ Enzyme 2.6.1.23 at KEGG Pathway Database.
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