4-Dimethylallyltryptophan N-methyltransferase
| 4-dimethylallyltryptophan N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.261 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
4-dimethylallyltryptophan N-methyltransferase (EC 2.1.1.261, fgaMT (gene), easF (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase.[1] It catalyses the following chemical reaction
-L-tryptophan.svg.png)
This is a methylation reaction in which the methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Aspergillus fumigatus. It catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in that fungus.[2]
References
- ↑ Enzyme 2.1.1.261 at KEGG Pathway Database.
- ↑ Rigbers O, Li SM (October 2008). "Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase". The Journal of Biological Chemistry. 283 (40): 26859–68. doi:10.1074/jbc.m804979200. PMID 18678866.
External links
- 4-dimethylallyltryptophan+N-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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