3-Hydroxydesalkylgidazepam

3-Hydroxydesalkylgidazepam
Identifiers
	IUPAC name 7-Bromo-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;
CAS Number	37891-18-2;
PubChem CID	627325;
Chemical and physical data
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Br)O;
	InChI InChI=1S/C15H11BrN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19); Key:POAUVEHBXZCMCD-UHFFFAOYSA-N;

3-Hydroxydesalkylgidazepam is a benzodiazepine derivative which has been sold as a designer drug, first reported in Ireland in 2025.^[1] It is closely related to the pharmaceutical benzodiazepine oxazepam but with the chloro substitution replaced by bromo, and has similar hypnotic, sedative, anticonvulsant, and anxiolytic actions. It is also a metabolite of the Russian benzodiazepine gidazepam. Various derivatives substituted on the OH group are known which act as prodrugs for 3-hydroxydesalkylgidazepam and related compounds.^[2]^[3]

References

↑ Jeffers MR, Greer WR (6 June 2026). "Technical note: Identification of the novel benzodiazepine 3-hydroxy desalkylgidazepam within PSNI tablet seizures in northern Ireland". Journal of Forensic and Legal Medicine. 121 103187. doi:10.1016/j.jflm.2026.103187. PMID 42269423.
↑ Pavlovsky VI, Semenishina EA, Kravchenko IA, Radaeva IN, Simonov YA, Gdaniec M, et al. (December 2012). "Synthesis and anticonvulsant activity of 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones". Pharmaceutical Chemistry Journal. 46 (9): 540–545. doi:10.1007/s11094-012-0842-9.
↑ Pavlovsky VI, Karaseva TL, Semenishina EA, Andronati KS, Yurpalova TA, Onufrienko OV, et al. (2019-06-15). "Synthesis, Affinity for Central Benzodiazepine Receptors, and Hypnosedative and Anxiolytic Properties of 3-Acyloxy-5-Aryl-7-Bromo-1,2-Dihydro-3H-1,4-Benzodiazepin-2-Ones". Pharmaceutical Chemistry Journal. 53 (3): 207–211. doi:10.1007/s11094-019-01980-7.

[1] Jeffers MR, Greer WR (6 June 2026). "Technical note: Identification of the novel benzodiazepine 3-hydroxy desalkylgidazepam within PSNI tablet seizures in northern Ireland". Journal of Forensic and Legal Medicine. 121 103187. doi:10.1016/j.jflm.2026.103187. PMID 42269423.

[2] Pavlovsky VI, Semenishina EA, Kravchenko IA, Radaeva IN, Simonov YA, Gdaniec M, et al. (December 2012). "Synthesis and anticonvulsant activity of 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones". Pharmaceutical Chemistry Journal. 46 (9): 540–545. doi:10.1007/s11094-012-0842-9.

[3] Pavlovsky VI, Karaseva TL, Semenishina EA, Andronati KS, Yurpalova TA, Onufrienko OV, et al. (2019-06-15). "Synthesis, Affinity for Central Benzodiazepine Receptors, and Hypnosedative and Anxiolytic Properties of 3-Acyloxy-5-Aryl-7-Bromo-1,2-Dihydro-3H-1,4-Benzodiazepin-2-Ones". Pharmaceutical Chemistry Journal. 53 (3): 207–211. doi:10.1007/s11094-019-01980-7.

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See also

References