2CT-2-EtO
 | |
| Clinical data | |
|---|---|
| Other names | 2CT-2EtO; 2CT-2-ETO; 2CT-2ETO; 2C-T-2-EtO; 2-Ethoxy-5-methoxy-4-methylthiophenethylamine; 2-Ethoxy-4-methylthio-5-methoxyphenethylamine |
| Routes of administration | Oral[1][2][3] |
| Drug class | Psychoactive drug |
| ATC code |
|
| Pharmacokinetic data | |
| Onset of action | "Very quick"[1] |
| Duration of action | 4 hours[1][2][3] |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C12H19NO2S |
| Molar mass | 241.35 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
2CT-2-EtO, also known as 2-ethoxy-5-methoxy-4-methylthiophenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-T.[1][2][3] It is the derivative of 2C-T in which the methoxy group at the 2 position has been replaced with an ethoxy group.[1][2][3]
According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT-2-EtO's dose is 50 mg orally and its duration is 4 hours.[1][2][3] It is said to have a "very quick" onset.[1] The effects of 2CT-2-EtO are said to be "mild", reaching no greater than a "plus-one" on the Shulgin Rating Scale, and were reported to include blurred vision, with no other specific effects described.[1][2][3] Higher doses of the drug were not assessed.[1][2][3]
The chemical synthesis of 2CT-2-EtO has been described.[1]
2CT-2-EtO was first described in the literature by Shulgin in PiHKAL in 1991.[1] It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin.[2][4][5][6][7] The drug is a controlled substance in Canada under phenethylamine blanket-ban language.[8]
See also
References
- 1 2 3 4 5 6 7 8 9 10 11 Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. "Both of the homologous mono-ethoxy Tweetios of 2C-T have been synthesized and evaluated. The 2-EtO-homologue of 2C-T is 2-ethoxy-5-methoxy-4-methylthiophenethylamine, or 2CT-2ETO. The benzaldehyde (2-ethoxy-5-methoxy-4-(methylthio)benzaldehyde) was an oil, the nitrostyrene intermediate had a melting point of 137–138 °C, and the final hydrochloride a melting point of 215–216 °C. The effects were felt very quickly, and there was a blurring of vision. However, the highest dose tried, 50 milligrams, was not able to produce a greater-than-plus one state, and what did occur, lasted for only 4 hours."
- 1 2 3 4 5 6 7 8 Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
- 1 2 3 4 5 6 7 Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
- ↑ "Erowid Darrell Lemaire Vault". erowid.org. Retrieved 14 November 2025.
- ↑ Morris H (7 December 2016). "The Lazy Lizard School of Hedonism". Hamilton's Pharmacopeia. Season 1. Episode 6. Vice Media. Viceland.
- ↑ Nez H, Lemaire D (2010). "Notes About Psychoactive Compounds" (PDF). In Targ R, Radin D (eds.). Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. pp. 201–207. ISBN 978-0-615-29633-3.
- ↑ Nez H, Lemaire D (Lazar) (1990). Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). Archived from the original (PDF) on 9 July 2001.
- ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.